粘接
粘接
점접
2014年
4期
58-63
,共6页
聚合物纳米胶束%药物控释%刺激响应性%嵌段共聚物
聚閤物納米膠束%藥物控釋%刺激響應性%嵌段共聚物
취합물납미효속%약물공석%자격향응성%감단공취물
polymer nano-micelles%controlled drug delivery%stimuli-responsiveness%block copolymers
聚合物纳米胶束不仅可以提高药物的溶解度、生物利用度，延长药物在人体内的循环时间，还可以有效控制药物的释放而实现靶向治疗效果，极大地减少药物对人体的副作用。通过嵌段共聚物的纳米工程，可制备出具有细胞或组织靶向性且对物理或化学刺激敏感的高分子药物载体。本文综述了对pH值、温度、超声波和光具有响应性的聚合物纳米胶束的制备及其在药物控制释放领域的应用。
聚閤物納米膠束不僅可以提高藥物的溶解度、生物利用度，延長藥物在人體內的循環時間，還可以有效控製藥物的釋放而實現靶嚮治療效果，極大地減少藥物對人體的副作用。通過嵌段共聚物的納米工程，可製備齣具有細胞或組織靶嚮性且對物理或化學刺激敏感的高分子藥物載體。本文綜述瞭對pH值、溫度、超聲波和光具有響應性的聚閤物納米膠束的製備及其在藥物控製釋放領域的應用。
취합물납미효속불부가이제고약물적용해도、생물이용도，연장약물재인체내적순배시간，환가이유효공제약물적석방이실현파향치료효과，겁대지감소약물대인체적부작용。통과감단공취물적납미공정，가제비출구유세포혹조직파향성차대물리혹화학자격민감적고분자약물재체。본문종술료대pH치、온도、초성파화광구유향응성적취합물납미효속적제비급기재약물공제석방영역적응용。
The polymer micelles can improve the drug solubility and bioavailability and prolong the cycle time of drugs in the body, and also can control the drug release to achieve the targeted therapy,reducing the side effects on the body.The polymer drug carriers with the cell or tissue targeting and the chemical or physical stimuli-sensitivity can be fabricated by the nano-engineering of block copolymers.The polymer micelles with pH, temperature, ultrasound and light responsiveness and their applications in the field of controlled drug delivery are reviewed in detail.
