CAJ | 학술논문

目的：探讨海洛因依赖者与健康对照者大脑神经元自发活动的差异。方法应用3.0T 磁共振扫描仪，采集20例男性海洛因依赖者(海洛因组)与15例人口学匹配的健康志愿者(对照组)静息态 fMRI 数据，比较2组间低频振幅的差异。结果与对照组相比，海洛因组喙侧扣带回脑区(双侧前扣带回、内侧前额叶)低频振幅活动明显减弱，未发现低频振幅增强的区域。结论海洛因依赖者静息态下喙侧扣带回区域功能异常，这可能导致海洛因依赖者认知功能损伤，且在成瘾者复吸想法转变为行为的过程中具有重要作用。
목적：탐토해락인의뢰자여건강대조자대뇌신경원자발활동적차이。방법응용3.0T 자공진소묘의，채집20례남성해락인의뢰자(해락인조)여15례인구학필배적건강지원자(대조조)정식태 fMRI 수거，비교2조간저빈진폭적차이。결과여대조조상비，해락인조훼측구대회뇌구(쌍측전구대회、내측전액협)저빈진폭활동명현감약，미발현저빈진폭증강적구역。결론해락인의뢰자정식태하훼측구대회구역공능이상，저가능도치해락인의뢰자인지공능손상，차재성은자복흡상법전변위행위적과정중구유중요작용。
Objective To explore the changes of cerebral local neuronal spontaneous activity between heroin dependent individuals and normal controls.Methods 3.0 T MRI were used for data acquisition,fMRI data were acquired during resting state from 20 male heroin dependent individuals(HD)and 1 5 matched normal controls(NC),and then the difference of amplitude of low frequency fluctuation (ALFF)between groups were analysised.Results Compared with NC,ALFF in rostral cingulated zone(bilateral anteri-or cingulate cortex ,medial prefrontal cortex )was significantly reduced in HD.Conclusion Dysfunction of resting state in RCZ were observed in HD,which may result in cognitive impairment and plays an important role in the transitions from ideas into behav-ior of relapse in addiction.