CAJ | 학술논문

目的：评价亚砷酸胸腔注射治疗恶性胸腔积液的临床价值。方法：恶性胸腔积液患者68例，均经细胞学和病理学确诊。随机分为治疗组和对照组，在胸膜腔积液充分引流后，治疗组36例，胸膜腔内注射亚砷酸10-20mg，每天或隔日1次，连续3次。对照组32例，胸膜腔内注射博莱霉素30mg/ m2，7天1次，共1-2次。观察疗效、毒副反应、生活质量。结果：治疗组 CR 10例（27.78%），PR 16例（44.44%），总有效率为72.22%（26/36）；对照组 CR 8例（25.00%），PR 15例（46.88%），总有效率为71.88%（23/32），两组有效率差异无显著性（P ﹥0.05）。治疗组注药后胸痛反应明显低于对照组（P ﹤0.05），胃肠道反应、骨髓抑制、发热反应两组间无明显差异（P ﹥0.05）。治疗后两组 KPS 评分均有增加，治疗前后比较有明显差异（P ﹤0.05）。结论：亚砷酸胸腔注射治疗恶性胸腔积液是一种有效、安全的方法。
목적：평개아신산흉강주사치료악성흉강적액적림상개치。방법：악성흉강적액환자68례，균경세포학화병이학학진。수궤분위치료조화대조조，재흉막강적액충분인류후，치료조36례，흉막강내주사아신산10-20mg，매천혹격일1차，련속3차。대조조32례，흉막강내주사박래매소30mg/ m2，7천1차，공1-2차。관찰료효、독부반응、생활질량。결과：치료조 CR 10례（27.78%），PR 16례（44.44%），총유효솔위72.22%（26/36）；대조조 CR 8례（25.00%），PR 15례（46.88%），총유효솔위71.88%（23/32），량조유효솔차이무현저성（P ﹥0.05）。치료조주약후흉통반응명현저우대조조（P ﹤0.05），위장도반응、골수억제、발열반응량조간무명현차이（P ﹥0.05）。치료후량조 KPS 평분균유증가，치료전후비교유명현차이（P ﹤0.05）。결론：아신산흉강주사치료악성흉강적액시일충유효、안전적방법。
Objective:To evaluate the clinical value of arsenic trioxide in treating malignant Pleural effusion by in-jecting into Pleural cavity. Methods:Sixty - eight Patients,required to have a cytologically Positive Pleural effusion or a Positive Pleural bioPsy in the Presence of an exudative effusion. After the accumulation of Pleural fluid had been ad-equately drained,36 Patients were randomized to Arsenic trioxide grouP,receiving arsenic trioxide 10 - 20mg,once a day or once two days,on 3 successive times,which were administered via chest tube or directly injected into Pleural cavity. Then the efficacy,toxicity and Perform ancestatus were evaluated. Results:In the Arsenic trioxide grouP,10 Pa-tients(27. 78% )achieved CR and 16 Patients(44. 44% )PR,the overall resPonse rate was 72. 22%(26 / 36). The control grouP 8 Patients(25. 00% )achieved CR and 15 Patients( 46 . 88 % )PR,and the overall resPonse rate was 71. 88%(23 / 32). The two grouPs had no significant difference in efficiency(P ﹥ 0. 05). The incidence rate of chest Pain after injection in arsenic trioxide grouP was significantly lower than the control grouP(P ﹤ 0. 05),gastroin-testinal tract,bone marrow suPPression,fever was no significant difference between the two grouPs(P ﹥ 0. 05). After treatment KPS scores were increased,there are significant differences before and after treatment(P ﹤ 0. 05). Conclu-sion:The treatment of malignant Pleural effusion with arsenic trioxide is effective,safe with little side effects.