CAJ | 학술논문

目的：了解宫颈癌高危人乳头瘤病毒（HR-HPV）型别分布特征。方法系统检索PubMed数据库和《中国期刊全文数据库》收录的2000年1月-2013年1月的文献，摘录相关信息，分别采用直接等权相加和广义倒方差模型进行Meta分析。结果共纳入33篇文献，总HR-HPV感染率为86.41％（95％CI：85.44％～87.38％），感染率前5位的HPV型别为HPV16、HPV18、HPV58、HPV52和HPV33。广义倒方差模型分析总HR-HPV感染率为86.99％（95％CI：83.45％～90.69％），纳入的各研究间异质性较大（I2＝90.19％，P＜0.05）。引物为SPF10的PCR检测方法检测出的HR-HPV感染率最高，为97.23％（95％CI：96.11％～98.35％）。结论我国妇女宫颈癌中HR-HPV感染型别以HPV16、HPV18、HPV58、HPV52和HPV33为主，不同地区HR-HPV型别分布存在差异。
목적：료해궁경암고위인유두류병독（HR-HPV）형별분포특정。방법계통검색PubMed수거고화《중국기간전문수거고》수록적2000년1월-2013년1월적문헌，적록상관신식，분별채용직접등권상가화엄의도방차모형진행Meta분석。결과공납입33편문헌，총HR-HPV감염솔위86.41％（95％CI：85.44％～87.38％），감염솔전5위적HPV형별위HPV16、HPV18、HPV58、HPV52화HPV33。엄의도방차모형분석총HR-HPV감염솔위86.99％（95％CI：83.45％～90.69％），납입적각연구간이질성교대（I2＝90.19％，P＜0.05）。인물위SPF10적PCR검측방법검측출적HR-HPV감염솔최고，위97.23％（95％CI：96.11％～98.35％）。결론아국부녀궁경암중HR-HPV감염형별이HPV16、HPV18、HPV58、HPV52화HPV33위주，불동지구HR-HPV형별분포존재차이。
Objective This study aimed to explore the overall prevalence and type distribution of High Risk Human Papilloma Virus (HR -HPV)in invasive cervical cancer in China.Methods Literatures published on China National Knowledge Infrastructure (CNKI)and PubMed database from January 2000 to January 2013 were systematically searched. The generic inverse variance model and direct equal -weighted sum model were used.Results 33 studies were included in this meta -analysis.The pooled infectious rate of HR -HPV was 86.41% (95%confidence interval (CI)85.44% -87.38%).Top five HR -HPV types in invasive cervical cancer (ICC)women were HPV16,HPV18,HPV58,HPV52 and HPV33.The generic inverse variance model showed the pooled infectious rate of HR -HPV types was 86.99%(95%CI 83.45% -90.69%)with a significant heterogeneity among studies (I2 =90.19%,P <0.05).The infectious rate of HR -HPV in northern China was significantly higher than that in southern China (P <0.05).Conclusion The main types of HR -HPV infection are HPV16,HPV18,HPV58,HPV52 and HPV33 in China and the distribution varies in regions.