CAJ | 학술논문

目的：评价 MLe1、MSe2、PMS2和 MSe6蛋白在子宫内膜癌中的表达缺失率，探讨 MMR 蛋白在子宫内膜癌发生、发展中的作用。方法：选取87例子宫内膜癌肿瘤组织，应用免疫组化方法检测子宫内膜癌组织中 MLe1、MSe2、PMS2和 MSe6蛋白的表达。结果：87例子宫内膜癌中 MLe1、MSe2、PMS2和 MSe6四种蛋白表达缺失率分别为12.6%（11/87）、2.3%（2/87）、16.1%（14/87）、6.9%（6/87），总的蛋白缺失率为31.0%（27/87）。MMR 蛋白在不同年龄段的表达缺失率依次为：≤30岁为0%（0/2）、31-40岁为43.8%（7/16）、41-50岁为44.4%（12/27）、﹥50岁为19.0%（8/42）。I 型子宫内膜样腺癌的 MMR 蛋白缺失率为36.9%，其中高级别的子宫内膜样腺癌中 MMR 蛋白表达缺失率为58.3%；II 型子宫内膜癌中 MMR 蛋白的表达缺失率为13.6%。MMR 蛋白在黏膜内癌、浅肌层浸润癌及深肌层浸润癌中的表达缺失率分别为14.3%（3/21）、29.6%（16/54）、66.7%（8/12），10例淋巴结转移的子宫内膜癌病例中有6例存在 MMR 蛋白的表达缺失。结论：MMR 蛋白在低年龄段、高级别子宫内膜样腺癌、有深肌层浸润及淋巴结转移的子宫内膜癌病例中表达缺失率高，MMR 蛋白在子宫内膜癌的进展中具有重要作用，建议临床常规检测子宫内膜癌中 MMR 蛋白的表达。
목적：평개 MLe1、MSe2、PMS2화 MSe6단백재자궁내막암중적표체결실솔，탐토 MMR 단백재자궁내막암발생、발전중적작용。방법：선취87례자궁내막암종류조직，응용면역조화방법검측자궁내막암조직중 MLe1、MSe2、PMS2화 MSe6단백적표체。결과：87례자궁내막암중 MLe1、MSe2、PMS2화 MSe6사충단백표체결실솔분별위12.6%（11/87）、2.3%（2/87）、16.1%（14/87）、6.9%（6/87），총적단백결실솔위31.0%（27/87）。MMR 단백재불동년령단적표체결실솔의차위：≤30세위0%（0/2）、31-40세위43.8%（7/16）、41-50세위44.4%（12/27）、﹥50세위19.0%（8/42）。I 형자궁내막양선암적 MMR 단백결실솔위36.9%，기중고급별적자궁내막양선암중 MMR 단백표체결실솔위58.3%；II 형자궁내막암중 MMR 단백적표체결실솔위13.6%。MMR 단백재점막내암、천기층침윤암급심기층침윤암중적표체결실솔분별위14.3%（3/21）、29.6%（16/54）、66.7%（8/12），10례림파결전이적자궁내막암병례중유6례존재 MMR 단백적표체결실。결론：MMR 단백재저년령단、고급별자궁내막양선암、유심기층침윤급림파결전이적자궁내막암병례중표체결실솔고，MMR 단백재자궁내막암적진전중구유중요작용，건의림상상규검측자궁내막암중 MMR 단백적표체。
Objective:To evaluate the exPression of MLe1,MSe2,PMS2,and MSe6 Protein in endometrial canc-er and exPlore its role in endometrial cancer occurrence and develoPment. Methods:To select tumor tissue of 87 en-dometrial cancer,the MLe1,MSe2,PMS2,and MSe6 Protein in these tumor tissue were detected by immunohisto-chemistry. Results:In the 87 tumor tissues,the exPression loss rates of MLe1,MSe2,PMS2,and MSe6 Protein were 12. 6%(11 / 87),2. 3%(2 / 87),16. 1%(14 / 87),6. 9%(6 / 87). The total exPression loss rate of four MMR Protein was 31. 0%(27 / 87). The exPression loss rate of MMR Protein in the different ages were 0%(≤30 years),43. 8%(31 to 40 years),44. 4%(41 to 50 years)and 19. 0%( ﹥ 50 years). The exPression loss rate of MMR Proteins was 36. 9% in the tyPe I endometrial adenocarcinoma,of which the exPression loss rate of MMR Protein was 58. 3% in the high grade endometrial adenocar - cinoma. The exPression loss rate of MMR Protein was 13. 6% in tyPe II endometrial cancer. The exPression loss rate of MMR Protein in the endometrial cancer with mucosal,suPerficial muscle invasive and deeP muscle invasive were 14. 3%(3 / 21),29. 6%(16 / 54),66. 7%(8 / 12). There were 6 Patients with the ex-Pression loss rates of MMR Proteins in the 10 cases endometrial cancer Patients with lymPh node metastasis. Conclu-sion:The exPression loss rate of MMR Protein was high in low - age,high grade luterine endometrioid adenocarcino-ma,deeP myometrial invasion and lymPh node metastasis of endometrial cancer cases. MMR Proteins Play an imPortant role in the Progress of endometrial cancer. We suggest testing MMR Protein in the endometrial cancer routinely.