现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2014年
5期
1096-1099
,共4页
畅智慧%郑加贺%王传卓%赵健%马羽佳%刘兆玉
暢智慧%鄭加賀%王傳卓%趙健%馬羽佳%劉兆玉
창지혜%정가하%왕전탁%조건%마우가%류조옥
结肠癌%肝转移瘤%复发%射频消融术%中性粒细胞与淋巴细胞比值
結腸癌%肝轉移瘤%複髮%射頻消融術%中性粒細胞與淋巴細胞比值
결장암%간전이류%복발%사빈소융술%중성립세포여림파세포비치
colorectal cancer%liver metastases%recurrence%radiofrequency ablation%neutroPhil - lymPhocyte ratio
目的：探讨外周血中性粒细胞与淋巴细胞比值（NLR）对结肠癌肝转移射频消融术后肿瘤复发的影响。方法：回顾性分析98例行射频消融术的结肠癌肝转移患者临床资料。单因素分析术前最大肿瘤直径、肿瘤数目、结肠癌病理分期、CEA 水平、术前和术后 NLR 等对术后无瘤生存率的影响。有统计学意义的影响因素进入 Cox 回归模型行多因素分析。结果：1、3、5年的无瘤生存率分别为66.3%、28.6%和17.3%。单因素分析显示术前 NLR≥2.5和术后 NLR 升高影响术后无瘤生存率。NLR ﹤2.5和 NLR≥2.5的患者1、3、5年无瘤生存率分别为77.4%、35.8%、22.6%和53.3%、20.0%、11.1%（P ＝0.044）。术后 NLR 升高和不升高的患者1、3、5年无瘤生存率分别为52.3%、17.1%、8.6%和73.0%、34.9%、22.2%（P ＝0.022）。Cox 回归分析显示仅术后 NLR 升高为影响结肠癌肝转移射频消融术后复发的独立危险因素（P ＝0.029）。结论：术前NLR≥2.5及术后 NLR 升高的结肠癌肝转移患者射频消融术后肿瘤复发的风险增加。
目的：探討外週血中性粒細胞與淋巴細胞比值（NLR）對結腸癌肝轉移射頻消融術後腫瘤複髮的影響。方法：迴顧性分析98例行射頻消融術的結腸癌肝轉移患者臨床資料。單因素分析術前最大腫瘤直徑、腫瘤數目、結腸癌病理分期、CEA 水平、術前和術後 NLR 等對術後無瘤生存率的影響。有統計學意義的影響因素進入 Cox 迴歸模型行多因素分析。結果：1、3、5年的無瘤生存率分彆為66.3%、28.6%和17.3%。單因素分析顯示術前 NLR≥2.5和術後 NLR 升高影響術後無瘤生存率。NLR ﹤2.5和 NLR≥2.5的患者1、3、5年無瘤生存率分彆為77.4%、35.8%、22.6%和53.3%、20.0%、11.1%（P ＝0.044）。術後 NLR 升高和不升高的患者1、3、5年無瘤生存率分彆為52.3%、17.1%、8.6%和73.0%、34.9%、22.2%（P ＝0.022）。Cox 迴歸分析顯示僅術後 NLR 升高為影響結腸癌肝轉移射頻消融術後複髮的獨立危險因素（P ＝0.029）。結論：術前NLR≥2.5及術後 NLR 升高的結腸癌肝轉移患者射頻消融術後腫瘤複髮的風險增加。
목적：탐토외주혈중성립세포여림파세포비치（NLR）대결장암간전이사빈소융술후종류복발적영향。방법：회고성분석98례행사빈소융술적결장암간전이환자림상자료。단인소분석술전최대종류직경、종류수목、결장암병리분기、CEA 수평、술전화술후 NLR 등대술후무류생존솔적영향。유통계학의의적영향인소진입 Cox 회귀모형행다인소분석。결과：1、3、5년적무류생존솔분별위66.3%、28.6%화17.3%。단인소분석현시술전 NLR≥2.5화술후 NLR 승고영향술후무류생존솔。NLR ﹤2.5화 NLR≥2.5적환자1、3、5년무류생존솔분별위77.4%、35.8%、22.6%화53.3%、20.0%、11.1%（P ＝0.044）。술후 NLR 승고화불승고적환자1、3、5년무류생존솔분별위52.3%、17.1%、8.6%화73.0%、34.9%、22.2%（P ＝0.022）。Cox 회귀분석현시부술후 NLR 승고위영향결장암간전이사빈소융술후복발적독립위험인소（P ＝0.029）。결론：술전NLR≥2.5급술후 NLR 승고적결장암간전이환자사빈소융술후종류복발적풍험증가。
Objective:To investigate the effect of PeriPheral blood neutroPhil - lymPhocyte ratio on the tumor re-currence of liver metastasis of colon cancer after radiofrequency ablation. Methods:To retrosPectively analyze 98 cases of radiofrequency ablation of liver metastasis of colon cancer. Univariate analysis was Performed on PreoPerative maxi-mal tumor diameter,tumor number,colon cancer staging,Pathological effects of CEA levels,PreoPerative and PostoPer-ative NLR with the PostoPerative disease - free survival rate,and then by multivariate analysis of Cox regression mod-el. Results:1,3,5 years disease - free survival rates were 66. 3% ,28. 6% and 17. 3% resPectively. Single factor a-nalysis showed PreoPerative NLR≥2. 5 and NLR after the oPeration affected increased PostoPerative disease - free survival rate. NLR ﹤ 2. 5 and NLR≥2. 5 were 1,3,5 years disease - free survival rates were 77. 4% ,35. 8% ,22. 6%and 53. 3% ,20. 0% ,11. 1% resPectively(P = 0. 044). Patients with elevated NLR after oPeration and no increased 1,3,5 years disease - free survival rate was 52. 3% ,17. 1% ,8. 6% and 73. 0% ,34. 9% ,22. 2% resPectively(P =0. 022). Cox regression analysis showed that only NLR elevation after oPeration was indePendent risk of recurrence of colon cancer liver metastasis after radiofrequency catheter ablation(P = 0. 029)factor. Conclusion:PreoPerative NLR≥2. 5 and NLR PostoPerative elevated liver metastasis of colon cancer after radiofrequency ablation in Patients were with an increased risk of tumor recurrence.
