CAJ | 학술논문

目的：观察放疗同期紫杉醇+奈达伯+氟尿嘧啶化疗治疗鼻咽癌的疗效及毒副反应。方法：81例确诊为鼻咽癌的患者随机分为治疗组（放疗同期 TNF 方案化疗组）41例和对照组（单纯放疗组）40例。治疗组在放射治疗的第1、4周给予 TNF 方案化疗及放疗后2个周期紫杉醇+奈达伯+氟尿嘧啶方案化疗。结果：治疗组1、3年生存率分别为100%（41/41）、82.9%（34/41）。对照组1、3年生存率分别为87.5%（35/40）、62.5%（25/40）（P ﹥0.05）。放化组3年生存率及局控率、远处转移控制率明显高于单纯放疗组，治疗组虽消化道反应及骨髓功能抑制明显较对照组发生率高，但与对照组相比无统计学差异。结论：放疗同期 TNF 化疗治疗鼻咽癌疗效好，毒副反应可耐受。
목적：관찰방료동기자삼순+내체백+불뇨밀정화료치료비인암적료효급독부반응。방법：81례학진위비인암적환자수궤분위치료조（방료동기 TNF 방안화료조）41례화대조조（단순방료조）40례。치료조재방사치료적제1、4주급여 TNF 방안화료급방료후2개주기자삼순+내체백+불뇨밀정방안화료。결과：치료조1、3년생존솔분별위100%（41/41）、82.9%（34/41）。대조조1、3년생존솔분별위87.5%（35/40）、62.5%（25/40）（P ﹥0.05）。방화조3년생존솔급국공솔、원처전이공제솔명현고우단순방료조，치료조수소화도반응급골수공능억제명현교대조조발생솔고，단여대조조상비무통계학차이。결론：방료동기 TNF 화료치료비인암료효호，독부반응가내수。
Objective:To observe the theraPeutic effects and side effects of radiotheraPy in advanced nasoPharyn-geal carcinoma(NPC). Methods:A total of 81 advanced NPC Patients were randomly allocated into CRT grouP and RT grouP. The Patients in CRT grouP were treated by radiotheraPy combined with four cycles of TNF(chemotheraPy, of which two cycles were given in the 1th and 4th week during RT and the other two after RT. The Patients in RT grouP were treated by radiotheraPy alone. Results:CRT grouP 1,3 - year survival rates were 100%(41 / 41),82. 9%(34 / 41). The RT grouP 1,3 - year survival rates were 87. 5%(35 / 40),62. 5%(25 / 40)(P ﹥ 0. 05). ComPared with RT grouP,the 3 - year rate of survival,loco - control and metastasis in CRT grouP was significantly higher. The incidence of gastrointestinal and hematological toxicity in CRT were higher than that in RT,but without significant difference. Conclusion:The effects of radiotheraPy combined with TNF chemotheraPy in advanced nasoPharyngeal car-cinoma(NPC)is satisfied and toxicity were tolerable.