CAJ | 학술논문

通过转染特定的一个或多个基因将已分化的体细胞诱导成为多潜能干细胞,这种干细胞称为诱导性多潜能干细胞(Induced pluripotent stem cells,iPS cells)。近年来关于iPS细胞的研究取得了举世瞩目的成就,多种已分化的体细胞都可以诱导成为iPS细胞,而且可以进一步将iPS细胞诱导成具有特定功能的细胞,称为诱导性细胞。这些研究极大地促进了细胞生物学、表观遗传学和发育生物学的研究,并且为人类再生医学和特异的细胞治疗带来了更美好的希望。对iPS细胞和诱导性细胞的最新研究状况进行了综述。
통과전염특정적일개혹다개기인장이분화적체세포유도성위다잠능간세포,저충간세포칭위유도성다잠능간세포(Induced pluripotent stem cells,iPS cells)。근년래관우iPS세포적연구취득료거세촉목적성취,다충이분화적체세포도가이유도성위iPS세포,이차가이진일보장iPS세포유도성구유특정공능적세포,칭위유도성세포。저사연구겁대지촉진료세포생물학、표관유전학화발육생물학적연구,병차위인류재생의학화특이적세포치료대래료경미호적희망。대iPS세포화유도성세포적최신연구상황진행료종술。
Differentiated somatic cells can be reprogrammed into induced pluripotent stem cells (iPS cells) by transfection of one or more gene (S). Remarkable progresses of iPS cells have been achieved in recent years. A variety of differentiated so-matic cells can be reprogrammed into iPS cells and further induced into cells with specific function called induced cells. These researches have greatly boosted the study of cell biology, epigenetics, developmental biology and brought a better hope for regenerative medicine and specific cell therapy. In this paper, advances of induced pluripotent stem cells (iPS cells) and induced functional cells (induced cells) in recent years were reviewed.