CAJ | 학술논문

目的：探讨血清降钙素原( PCT)检测在小儿颅内感染鉴别诊断中的应用价值。方法选择2011年5月-2013年5月暨南大学第二临床医学院附属深圳市人民医院儿科收治的颅内感染患儿95例分为急性细菌性脑膜炎组(细菌组,n=46)及病毒性脑炎组(病毒组,n=49),比较两组治疗前、后脑脊液(CSF)白细胞数、蛋白定量及血清PCT水平的变化,并比较两组不同血清PCT阶梯浓度水平检出分布及阳性率。结果治疗前,细菌组和病毒组CSF白细胞计数、蛋白定量及血清PCT水平差异均有统计学意义(P<0．01)；治疗后,两组CSF白细胞计数、蛋白定量差异无统计学意义(P>0．05),而PCT水平血清差异仍有统计学意义(P<0．01)；病毒组治疗前、后各指标比较差异均无统计学意义(P>0．05),细菌组治疗前、后各指标比较差异均有统计学意义(P<0．05)。两组不同PCT浓度值检出分布比较差异有统计学意义(Z=6.71, P=0．000)；病毒组及细菌组血清PCT阳性检出率分别为18.4%和80.4%,两组比较差异有统计学意义(χ2=35.60, P=0．000)。结论血清PCT可作为鉴别急性细菌性脑膜炎及病毒性脑炎的重要指标,其检测程序简便、快捷,值得临床广泛开展。
목적：탐토혈청강개소원( PCT)검측재소인로내감염감별진단중적응용개치。방법선택2011년5월-2013년5월기남대학제이림상의학원부속심수시인민의원인과수치적로내감염환인95례분위급성세균성뇌막염조(세균조,n=46)급병독성뇌염조(병독조,n=49),비교량조치료전、후뇌척액(CSF)백세포수、단백정량급혈청PCT수평적변화,병비교량조불동혈청PCT계제농도수평검출분포급양성솔。결과치료전,세균조화병독조CSF백세포계수、단백정량급혈청PCT수평차이균유통계학의의(P<0．01)；치료후,량조CSF백세포계수、단백정량차이무통계학의의(P>0．05),이PCT수평혈청차이잉유통계학의의(P<0．01)；병독조치료전、후각지표비교차이균무통계학의의(P>0．05),세균조치료전、후각지표비교차이균유통계학의의(P<0．05)。량조불동PCT농도치검출분포비교차이유통계학의의(Z=6.71, P=0．000)；병독조급세균조혈청PCT양성검출솔분별위18.4%화80.4%,량조비교차이유통계학의의(χ2=35.60, P=0．000)。결론혈청PCT가작위감별급성세균성뇌막염급병독성뇌염적중요지표,기검측정서간편、쾌첩,치득림상엄범개전。
Objective To explore the value of serum procalcitonin ( PCT) detection in differential diagnosis of intracranial infection in children. Methods A total of 95 children with intracranial infection admitted to department of pediatrics during May 2011 and May 2013 were divided into acute bacterial meningitis group ( bacteria group, n=46 ) and viral encephalitis (virus group, n=49). The changes of leukocyte counts of cerebrospinal fluid (CSF), protein quantification and serum PCT level were compared in the two groups before and after treatment, and the distribution and positive detection rate at different concentration levels of serum PCT were also compared between the two groups. Results Before the treatment, there were significant differences between the two groups in leukocyte counts of CSF, protein quantification and serum PCT level (P<0. 01);but there were no significant differences between the two groups in leu-kocyte counts of CSF and protein quantification after the treatment (P>0. 05), while there was significant difference in serum PCT level between the two groups (P<0. 01);there were no significant differences in the indexes in virus group before and after the treatment (P>0. 05), but there were significant differences in the indexes in bacteria group before and after the treatment (P<0. 05). The difference in detection distribution at different concentration levels of serum PCT in the two groups was statistically significant (Z=6. 71, P=0. 000);and the positive detection rate of serum PCT was 18. 4% in virus group and 80. 4% in bacteria group respectively, and the difference was also statistically significant (χ2 =35. 60, P=0. 000). Conclusion Serum PCT is an important index in differential diagnosis of acute bacterial meningitis and viral encephalitis and the method of serum PCT test is simple, quick and clinically worthy.