CAJ | 학술논문

目的：运用meta分析方法综合评价中国人群脑卒中的发病危险因素。方法对2003年1月-2012年6月国内发表的有关中国人群脑卒中发病危险因素的研究文献进行meta分析。结果本研究共纳入8篇文献,累计病例5416例,对照10473例。危险因素中高血压病、糖尿病、心脏病、动脉粥样硬化、高脂血症、家族史、吸烟和饮酒的比值比(OR)均>1,差异有统计学意义(P<0.05)；性别和肥胖的95%可信区间均包含1,尚不能确定其与脑卒中的关系；高血压病的归因危险度最高(69.16%)。漏斗图分析：高血压病和糖尿病存在发表性偏倚；敏感性分析：家族史为脑卒中发病危险因素的稳定性较差。结论现有证据表明,高血压病、心脏病、糖尿病、高脂血症、动脉粥样硬化、吸烟、饮酒和家族史是中国人群脑卒中发病的危险因素。
목적：운용meta분석방법종합평개중국인군뇌졸중적발병위험인소。방법대2003년1월-2012년6월국내발표적유관중국인군뇌졸중발병위험인소적연구문헌진행meta분석。결과본연구공납입8편문헌,루계병례5416례,대조10473례。위험인소중고혈압병、당뇨병、심장병、동맥죽양경화、고지혈증、가족사、흡연화음주적비치비(OR)균>1,차이유통계학의의(P<0.05)；성별화비반적95%가신구간균포함1,상불능학정기여뇌졸중적관계；고혈압병적귀인위험도최고(69.16%)。루두도분석：고혈압병화당뇨병존재발표성편의；민감성분석：가족사위뇌졸중발병위험인소적은정성교차。결론현유증거표명,고혈압병、심장병、당뇨병、고지혈증、동맥죽양경화、흡연、음주화가족사시중국인군뇌졸중발병적위험인소。
Objective To comprehensively evaluate the risk factors in Chinese population with cerebral stroke by Meta analysis. Methods Clinical data of the risk factors in patients with cerebral stroke from January to June 2003 un-derwent Meta analysis with case-control literature abroad and in China. Results The 8 pieces of research articles includ-ed 5416 cases and 10 473 control cases. The odds ratios ( OR) of hypertension, diabetes, heart disease, atherosclerosis, hyperlipidemia, family history, history of smoking and alcohol drinking were all higher than 1, and there were significant differences (P<0. 05);the 95% confidence intervals of gender and obesity all included 1, but the relations with stroke could not be confirmed;hypertension percentage of attributable risk was the highest (69. 16%). Conclusion Risk fac-tors in Chinese population with cerebral stroke are hypertension, heart disease, diabetes, hyperlipidemia, atherosclero-sis, smoking, alcohol drinking and family history as the current evidence shows.