CAJ | 학술논문

目的：探讨子宫肌瘤患者应用曼月乐的安全性。方法：选取我院子宫肌瘤患者165例，其中54例因同时伴有月经过多或子宫内膜息肉等非恶性病变，在子宫内置入曼月乐（曼月乐组）；另外111例无伴随症状，单纯行子宫肌瘤随访观察为对照组，两组患者均随访观察3年，比较两组患者子宫肌瘤体积的变化情况。结果：曼月乐组的子宫肌瘤体积大部分缩小（55.6%），小部分无明显改变（22.2%），小部分增大（18.5%），而对照组则以增大为主，两组变化统计比较，差异具有统计学意义（P<0.05）；曼月乐组中发生子宫肌瘤明显增大达手术指征的比例与不受外来激素影响的对照组比较差异无统计学意义（P>0.05）。结论：子宫肌瘤患者应用曼月乐安全性高，月经过多或子宫内膜非恶性病变等合并有子宫肌瘤的患者可应用曼月乐治疗。
목적：탐토자궁기류환자응용만월악적안전성。방법：선취아원자궁기류환자165례，기중54례인동시반유월경과다혹자궁내막식육등비악성병변，재자궁내치입만월악（만월악조）；령외111례무반수증상，단순행자궁기류수방관찰위대조조，량조환자균수방관찰3년，비교량조환자자궁기류체적적변화정황。결과：만월악조적자궁기류체적대부분축소（55.6%），소부분무명현개변（22.2%），소부분증대（18.5%），이대조조칙이증대위주，량조변화통계비교，차이구유통계학의의（P<0.05）；만월악조중발생자궁기류명현증대체수술지정적비례여불수외래격소영향적대조조비교차이무통계학의의（P>0.05）。결론：자궁기류환자응용만월악안전성고，월경과다혹자궁내막비악성병변등합병유자궁기류적환자가응용만월악치료。
Objective:To investigate the safety of Mirena that applies in hysteromyoma patients. Methods:165 cases of hysteromyoma patients in our hospital were chosen, 54 cases of them had been put Mirena into uterus due to concomitances of non malignant lesions such as menorrhagia or endo-metrial polyp (Mirena group);the other 111 cases of patients who had no concomitances were only given follow-up observation (control group), two groups of patients were all followed-up for 3 years, then compared the changes of tumor size of two groups. Results:The tumor size of most of pa-tients in Mirena group had reduced (55.6%), small part of patients had no obvious change (22.2%) or enlarged (18.5%), while control group was mainly with enlarged, the differences of the size changes between two groups had statistical significance (P<0.05);the differences of the rate of hys-teromyoma that increased to operation indications in Mirena group and that of patients without external hormone effects in control group had no sta-tistical significance (P>0.05). Conclusion: It's safe that Mirena applies in hysteromyoma patients, hysteromyoma patients who combined with non malignant lesions such as menorrhagia or endometrial polyp should be treated by Mirena.