CAJ | 학술논문

选取痉挛型脑瘫患儿及正常儿童共82例，其中小龄[1~3(1.9依0.6)岁]患儿和大龄[3~12(5.5依1.9)岁]患儿各27例(观察组)，小龄[1~3(2.2依0.6)岁]和大龄[3~12(6.9依2.7)岁]正常儿童各14例(对照组)。采用ELISA法检测血清肿瘤坏死因子α( TNF-α)水平。结果显示小龄及大龄痉挛型脑瘫儿童血清TNF-α水平均较相应年龄正常儿童升高(P<0.01)；小龄痉挛型脑瘫儿童血清TNF-α水平较大龄痉挛型脑瘫儿童血清TNF-α水平升高( P<0.01)，而对照组内正常儿童的不同年龄段的血清TNF-α水平无明显差异；痉挛型脑性瘫痪患儿血清TNF-α水平较正常儿童增高(P<0.01)；TNF-α在痉挛型脑性瘫痪患儿体内持续过度表达，参与脑性瘫痪的后续脑损伤。
선취경련형뇌탄환인급정상인동공82례，기중소령[1~3(1.9의0.6)세]환인화대령[3~12(5.5의1.9)세]환인각27례(관찰조)，소령[1~3(2.2의0.6)세]화대령[3~12(6.9의2.7)세]정상인동각14례(대조조)。채용ELISA법검측혈청종류배사인자α( TNF-α)수평。결과현시소령급대령경련형뇌탄인동혈청TNF-α수평균교상응년령정상인동승고(P<0.01)；소령경련형뇌탄인동혈청TNF-α수평교대령경련형뇌탄인동혈청TNF-α수평승고( P<0.01)，이대조조내정상인동적불동년령단적혈청TNF-α수평무명현차이；경련형뇌성탄탄환인혈청TNF-α수평교정상인동증고(P<0.01)；TNF-α재경련형뇌성탄탄환인체내지속과도표체，삼여뇌성탄탄적후속뇌손상。
82 spastic cerebral palsy and normal children were selected, including 27 younger and 27 older spastic cerebral palsy( observation group) ,and 14 younger and older normal children( control group) . The tumor necrosis factor α( TNF-α) levels were measured in the serum with ELISA. The TNF-α levels in the serum of the younger and older spastic CP groups were higher than those of the control groups ( P<0.01 ) . In observation groups, the TNF-α levels of younger spastic cerebral palsy were higher than those of the older (P<0.01). On the contrary, the normal children in the control group of different ages had no difference of TNF-α. TNF-αexpression was signifi-cantly higher in the serum of the spastic CP group than that in the control group ( P<0.01 ) . TNF-α expressed continuously in vivo of children with spastic cerebral palsy involve subsequent brain injury.