中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
15期
2442-2449
,共8页
组织构建%骨组织工程%甲状旁腺激素相关肽%糖尿病%骨质疏松%骨折%国家自然科学基金
組織構建%骨組織工程%甲狀徬腺激素相關肽%糖尿病%骨質疏鬆%骨摺%國傢自然科學基金
조직구건%골조직공정%갑상방선격소상관태%당뇨병%골질소송%골절%국가자연과학기금
parathyroid hormone%diabetes mel itus%osteoporosis%osteoporotic fractures
背景：甲状旁腺激素相关肽是在伴有高钙血症的癌症患者中被发现的一种多肽类物质，作为一种潜在的促进骨折愈合的药物，具有重要的临床应用价值。<br> 目的：探讨甲状旁腺激素相关肽在糖尿病性骨质疏松骨折中的调控作用。<br> 方法：计算机检索医脉通中文文献数据库以及PubMed 1990至2013年期间有关甲状旁腺激素相关肽的文章。检索词分别为“甲状旁腺激素相关肽，糖尿病，骨质疏松性骨折”和“Parathyroid hormone related peptides， diabetes，osteoporotic fracture”。初检得到1279篇文献，最终纳入文章43篇进入结果分析。<br> 结果与结论：动物实验和临床研究表明：甲状旁腺激素相关肽对于骨折愈合有明显的促进作用，同时对于糖尿病相关的胰岛细胞功能缺陷有良好的修复作用；其类似物甲状旁腺激素已作为治疗骨折的临床用药。但是甲状旁腺激素相关肽的临床用药剂量，骨折愈合不同分期的具体使用方法包括联合用药还有待进一步研究。
揹景：甲狀徬腺激素相關肽是在伴有高鈣血癥的癌癥患者中被髮現的一種多肽類物質，作為一種潛在的促進骨摺愈閤的藥物，具有重要的臨床應用價值。<br> 目的：探討甲狀徬腺激素相關肽在糖尿病性骨質疏鬆骨摺中的調控作用。<br> 方法：計算機檢索醫脈通中文文獻數據庫以及PubMed 1990至2013年期間有關甲狀徬腺激素相關肽的文章。檢索詞分彆為“甲狀徬腺激素相關肽，糖尿病，骨質疏鬆性骨摺”和“Parathyroid hormone related peptides， diabetes，osteoporotic fracture”。初檢得到1279篇文獻，最終納入文章43篇進入結果分析。<br> 結果與結論：動物實驗和臨床研究錶明：甲狀徬腺激素相關肽對于骨摺愈閤有明顯的促進作用，同時對于糖尿病相關的胰島細胞功能缺陷有良好的脩複作用；其類似物甲狀徬腺激素已作為治療骨摺的臨床用藥。但是甲狀徬腺激素相關肽的臨床用藥劑量，骨摺愈閤不同分期的具體使用方法包括聯閤用藥還有待進一步研究。
배경：갑상방선격소상관태시재반유고개혈증적암증환자중피발현적일충다태류물질，작위일충잠재적촉진골절유합적약물，구유중요적림상응용개치。<br> 목적：탐토갑상방선격소상관태재당뇨병성골질소송골절중적조공작용。<br> 방법：계산궤검색의맥통중문문헌수거고이급PubMed 1990지2013년기간유관갑상방선격소상관태적문장。검색사분별위“갑상방선격소상관태，당뇨병，골질소송성골절”화“Parathyroid hormone related peptides， diabetes，osteoporotic fracture”。초검득도1279편문헌，최종납입문장43편진입결과분석。<br> 결과여결론：동물실험화림상연구표명：갑상방선격소상관태대우골절유합유명현적촉진작용，동시대우당뇨병상관적이도세포공능결함유량호적수복작용；기유사물갑상방선격소이작위치료골절적림상용약。단시갑상방선격소상관태적림상용약제량，골절유합불동분기적구체사용방법포괄연합용약환유대진일보연구。
BACKGROUND:Parathyroid hormone related peptides are accompanied by the syndrome of humoral hypercalcemia of malignancy. As a potential therapeutic drug of promoting the healing of bone fracture, parathyroid hormone related peptides have significant clinical application value. <br> OBJECTIVE:To explore the regulating effects of parathyroid hormone related peptides in diabetic osteoporotic fracture <br> METHODS:A computer-based online research of CNKI and PubMed databases was performed to col ect articles published between 1990 and 2013, with the key words“parathyroid hormone related peptides, diabetes, osteoporotic fracture”in Chinese and English. There were 1 279 articles after the initial survey. A total of 43 articles were included according inclusion and exclusion criteria. <br> RESULTS AND CONCLUSION:Animal and clinical experiments demonstrated that parathyroid hormone related peptides notably accelerate bone fracture healing, and improve the repair process of islet cellfunction defects that are related with diabetes. Meanwhile, as an analogue, parathyroid hormone has been identified as clinical medication in the treatment of fracture. But the appropriate dose, and method of application at the different stages of bone fracture healing and the problem of drug combination need further investigation.
