CAJ | 학술논문

背景：脑卒中后神经网络与运动功能的相关性尚未明确。 　　目的：应用磁共振弥散张量成像研究亚急性期脑梗死后神经网络受损情况，并分析其与神经功能缺陷及运动功能障碍的相关性。 　　方法：将19例亚急性期脑梗死患者和20名正常成人分别进行弥散张量成像检查，分析比较以下参数：各向异性分数、表观扩散系数和各向异性分数指数、表观扩散系数指数。同时对患者进行神经功能缺损和运动功能的各项量表评估，检测10 m步行速度。将脑梗死患者弥散张量成像的各项参数与各项量表及10 m步行速度进行相关性分析。 　　结果与结论：脑梗死患者各向异性分数指数和双侧内囊后肢的各向异性分数值均小于正常对照，且患侧内囊后肢的各向异性分数值小于健侧内囊后肢的各向异性分数值(P<0.05)。患侧内囊后肢的表观扩散系数值、表观扩散系数指数大于正常对照内囊后肢的表观扩散系数值和表观扩散系数指数(P<0.05)。患侧内囊后肢的表观扩散系数值、表观扩散系数指数与下肢Fugl-Meyer评分呈负相关(P <0.05)。提示弥散张量成像参数与下肢运动功能障碍密切相关。脑卒中后的局灶性病变造成神经网络缺损，是下肢运动功能障碍的主要原因。
배경：뇌졸중후신경망락여운동공능적상관성상미명학。 　　목적：응용자공진미산장량성상연구아급성기뇌경사후신경망락수손정황，병분석기여신경공능결함급운동공능장애적상관성。 　　방법：장19례아급성기뇌경사환자화20명정상성인분별진행미산장량성상검사，분석비교이하삼수：각향이성분수、표관확산계수화각향이성분수지수、표관확산계수지수。동시대환자진행신경공능결손화운동공능적각항량표평고，검측10 m보행속도。장뇌경사환자미산장량성상적각항삼수여각항량표급10 m보행속도진행상관성분석。 　　결과여결론：뇌경사환자각향이성분수지수화쌍측내낭후지적각향이성분수치균소우정상대조，차환측내낭후지적각향이성분수치소우건측내낭후지적각향이성분수치(P<0.05)。환측내낭후지적표관확산계수치、표관확산계수지수대우정상대조내낭후지적표관확산계수치화표관확산계수지수(P<0.05)。환측내낭후지적표관확산계수치、표관확산계수지수여하지Fugl-Meyer평분정부상관(P <0.05)。제시미산장량성상삼수여하지운동공능장애밀절상관。뇌졸중후적국조성병변조성신경망락결손，시하지운동공능장애적주요원인。
BACKGROUND:The interaction of neural network and motor function in post-stroke brain tissue remains unclear. OBJECTIVE:To observe neural network impairment fol owing subacute stroke by using diffusion tensor imaging, and to investigate the relationship with neurological defects and motor dysfunction. METHODS:A total of 19 patients after subactue stroke and 20 healthy adults were examined with diffusion tensor imaging. The fol owing parameters were compared:fractional anisotropy, apparent diffusion coefficient, asymmetry indices of fractional anisotropy and apparent diffusion coefficient. The neurological defect and motor function were evaluated with the corresponding scales. The 10-meter walking speed was measured. The correlation of diffusion tensor imaging parameters with the scale scores and 10-meter walking speed was analyzed. RESULTS AND CONCLUSION:The stroke group exhibited reduced fractional anisotropy value asymmetry and fractional anisotropy value in bilateral posterior limbs of the internal capsule. Apparent diffusion coefficient value asymmetry and apparent diffusion coefficient value in the posterior limb of the internal capsule were lower than control unaffected side (P<0.05). Apparent diffusion coefficient value and apparent diffusion coefficient value asymmetry in posterior limb of the internal capsule showed a strong negative correlation with Fugl-Meyer assessment scores of the lower extremities (P<0.05). Diffusion tensor imaging parameters is closely linked with motor dysfunction of the lower extremities in subacute stroke patients. Local stroke lesion-caused neurological defect is the leading cause of motor dysfunction of the lower extremities.