中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
18期
2830-2835
,共6页
解道宇%鞠建宝%于海玲%李娜%郝大鹏%隋爱华
解道宇%鞠建寶%于海玲%李娜%郝大鵬%隋愛華
해도우%국건보%우해령%리나%학대붕%수애화
实验动物%组织构建%鼻窦炎%动物模型%解剖%CT%兔%鼻腔%鼻窦
實驗動物%組織構建%鼻竇炎%動物模型%解剖%CT%兔%鼻腔%鼻竇
실험동물%조직구건%비두염%동물모형%해부%CT%토%비강%비두
sinusitis%paranasal sinuses%nasal cavity%models%animal
背景：以实验动物模拟人类相关疾病是研究疾病发生发生及治疗的基础，鼻腔、鼻窦疾病也需要恰当实验动物作为其模型。目的：观察兔鼻腔、鼻窦的CT和局部解剖表现，探讨兔应用于鼻窦炎动物模型的可行性。<br> 方法：利用CT使用常规鼻窦冠状位与水平位扫描新西兰兔，随后进行常规鼻腔、鼻窦解剖学观察。<br> 结果与结论：兔鼻中隔将鼻腔分为左右两个腔，鼻腔外侧壁由上颌鼻甲、中间鼻甲、内侧鼻甲、下鼻甲组成，上颌窦窦腔最大，筛窦、蝶窦、额窦相对较小，以上结构均对称分布。兔鼻腔、鼻窦在CT扫描下显示清晰。兔鼻腔、鼻窦的解剖与人类鼻腔、鼻窦解剖结构既有相似也有不同，其上颌窦解剖部位与人相似且窦腔较大便于操作，具有动物实验模型建立的可行性，适用于鼻窦炎动物模型建立，可应用于模拟人类鼻窦炎的研究。
揹景：以實驗動物模擬人類相關疾病是研究疾病髮生髮生及治療的基礎，鼻腔、鼻竇疾病也需要恰噹實驗動物作為其模型。目的：觀察兔鼻腔、鼻竇的CT和跼部解剖錶現，探討兔應用于鼻竇炎動物模型的可行性。<br> 方法：利用CT使用常規鼻竇冠狀位與水平位掃描新西蘭兔，隨後進行常規鼻腔、鼻竇解剖學觀察。<br> 結果與結論：兔鼻中隔將鼻腔分為左右兩箇腔，鼻腔外側壁由上頜鼻甲、中間鼻甲、內側鼻甲、下鼻甲組成，上頜竇竇腔最大，篩竇、蝶竇、額竇相對較小，以上結構均對稱分佈。兔鼻腔、鼻竇在CT掃描下顯示清晰。兔鼻腔、鼻竇的解剖與人類鼻腔、鼻竇解剖結構既有相似也有不同，其上頜竇解剖部位與人相似且竇腔較大便于操作，具有動物實驗模型建立的可行性，適用于鼻竇炎動物模型建立，可應用于模擬人類鼻竇炎的研究。
배경：이실험동물모의인류상관질병시연구질병발생발생급치료적기출，비강、비두질병야수요흡당실험동물작위기모형。목적：관찰토비강、비두적CT화국부해부표현，탐토토응용우비두염동물모형적가행성。<br> 방법：이용CT사용상규비두관상위여수평위소묘신서란토，수후진행상규비강、비두해부학관찰。<br> 결과여결론：토비중격장비강분위좌우량개강，비강외측벽유상합비갑、중간비갑、내측비갑、하비갑조성，상합두두강최대，사두、접두、액두상대교소，이상결구균대칭분포。토비강、비두재CT소묘하현시청석。토비강、비두적해부여인류비강、비두해부결구기유상사야유불동，기상합두해부부위여인상사차두강교대편우조작，구유동물실험모형건립적가행성，괄용우비두염동물모형건립，가응용우모의인류비두염적연구。
BACKGROUND:Using experimental animals to simulate diseases of human being is the basis of studying etiology and treatment of the diseases, so the diseases of nasal cavity and sinus need suitable experimental animals as models. <br> OBJECTIVE:To observe the regional anatomy of rhino-sinus in rabbits and its performance through CT imaging, and to discuss the feasibility of applying a rabbit model to the study of animal rhino-sinusitis. <br> METHODS:Routine coronal and axial scanning images of rhino-sinus of New Zealand rabbits were performed through Discovery CT750 HD. The rhino-sinus anatomy was then observed. <br> RESULTS AND CONCLUSION:The nasal septum is located on both sides of the nasal cavity. The lateral wal of rabbit nasal is composed of maxil ary turbinate, middle turbinate, the inside of the middle turbinate and inferior turbinate. The maxil ary sinus cavity is the largest one and ethmoid sinus, sphenoid sinus and frontal sinus are relatively much smal er. Al these sinuses are paired and symmetrical. The rhino-sinus in rabbit is displayed clearly in CT scan. The anatomical location of rabbit is similar to that of human;however, the maxil ary sinus of rabbit is greater than that of human correspondingly, which is suitable for operating and applying to surgical anatomy and imaging analysis. The rabbit model of rhino-sinus can be applied to simulate human rhino-sinusitis.
