临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2014年
4期
303-306
,共4页
于正洪%王新星%石亚琴%顾军%姜恩泽%余波%张新华%陈龙邦
于正洪%王新星%石亞琴%顧軍%薑恩澤%餘波%張新華%陳龍邦
우정홍%왕신성%석아금%고군%강은택%여파%장신화%진룡방
乳腺癌%胰岛素样生长因子-I受体%SUSD3%雌激素受体
乳腺癌%胰島素樣生長因子-I受體%SUSD3%雌激素受體
유선암%이도소양생장인자-I수체%SUSD3%자격소수체
Breast cancer%Insulin-like growth factor-I receptor (IGF-IR)%Sushi domain-containing protein 3 (SUSD3)%Estrogen receptor
目的：探讨胰岛素样生长因子-I受体（ IGF-IR）和SUSD3在乳腺癌组织中的表达情况，分析两者与临床病理特征的关系及其两者间的相关性。方法采用Max VisionTM免疫组化法检测100例乳腺癌组织和对应癌旁组织中IGF-IR、SUSD3的表达，并分析其与乳腺癌临床病理特征的关系。结果 IGF-IR在乳腺癌和癌旁组织中的阳性表达率分别为86?0％和3?0％（ P＜0?05），SUSD3在乳腺癌和癌旁组织中的阳性表达率分别为78?0％和2?0％（ P＜0?05）。乳腺癌组织中IGF-IR和SUSD3的表达与ER水平和病理类型有关（ P＜0?05），而与年龄、HER-2表达、Ki-67表达和分期均无关（ P＞0?05）。 IGF-IR和SUSD3在乳腺癌组织中的表达呈正相关（ r＝0?553，P＜0?01）。结论 IGF-IR、SUSD3可能与乳腺癌的发生、发展有关，与ER联合检测对判断乳腺癌预后和指导术后辅助治疗有重要意义。
目的：探討胰島素樣生長因子-I受體（ IGF-IR）和SUSD3在乳腺癌組織中的錶達情況，分析兩者與臨床病理特徵的關繫及其兩者間的相關性。方法採用Max VisionTM免疫組化法檢測100例乳腺癌組織和對應癌徬組織中IGF-IR、SUSD3的錶達，併分析其與乳腺癌臨床病理特徵的關繫。結果 IGF-IR在乳腺癌和癌徬組織中的暘性錶達率分彆為86?0％和3?0％（ P＜0?05），SUSD3在乳腺癌和癌徬組織中的暘性錶達率分彆為78?0％和2?0％（ P＜0?05）。乳腺癌組織中IGF-IR和SUSD3的錶達與ER水平和病理類型有關（ P＜0?05），而與年齡、HER-2錶達、Ki-67錶達和分期均無關（ P＞0?05）。 IGF-IR和SUSD3在乳腺癌組織中的錶達呈正相關（ r＝0?553，P＜0?01）。結論 IGF-IR、SUSD3可能與乳腺癌的髮生、髮展有關，與ER聯閤檢測對判斷乳腺癌預後和指導術後輔助治療有重要意義。
목적：탐토이도소양생장인자-I수체（ IGF-IR）화SUSD3재유선암조직중적표체정황，분석량자여림상병리특정적관계급기량자간적상관성。방법채용Max VisionTM면역조화법검측100례유선암조직화대응암방조직중IGF-IR、SUSD3적표체，병분석기여유선암림상병리특정적관계。결과 IGF-IR재유선암화암방조직중적양성표체솔분별위86?0％화3?0％（ P＜0?05），SUSD3재유선암화암방조직중적양성표체솔분별위78?0％화2?0％（ P＜0?05）。유선암조직중IGF-IR화SUSD3적표체여ER수평화병리류형유관（ P＜0?05），이여년령、HER-2표체、Ki-67표체화분기균무관（ P＞0?05）。 IGF-IR화SUSD3재유선암조직중적표체정정상관（ r＝0?553，P＜0?01）。결론 IGF-IR、SUSD3가능여유선암적발생、발전유관，여ER연합검측대판단유선암예후화지도술후보조치료유중요의의。
Objective To investigate the expression of insulin-like growth factor-I receptor ( IGF-IR) and sushi domain-con-taining protein 3 ( SUSD3) in breast cancer tissue, and analyze their relationship with clinical parameters and the correlation between the two proteins. Methods The expression of IGF-IR and SUSD3 in 100 cases of beast cancer tissues and the corresponding adjacent normal breast tissues after surgery was detected by immunohistochemical technique MaxVisionTM , and the relationship with clinical pathological features was further analyzed. Results The positive rate of IGF-IR protein was 86.0% in breast cancer tissues, higher than 3.0% in adjacent normal breast tissues(P<0.05).The positive expression rate of SUSD3 protein was 78.0% in breast cancer tis-sues, higher than 2.0% in adjacent normal breast tissues( P<0.05) . The expression of IGF-IR and SUSD3 was related to estrogen re-ceptor and pathological types ( P<0.05) , but not with age, stage, the expression of HER-2 and Ki-67( P>0. 05) . The expression of IGF-IR and SUSD3 in breast cancer tissue was positively related ( r=0.553, P<0.01) . Conclusion The expression of IGF-IR and SUSD3 may be correlated to the occurrence and development of breast cancer. The combined detection of IGF-IR, SUSD3 and ER may play an important role in judging prognosis and guiding adjuvant therapy after surgery of breast cancer.
