临床儿科杂志
臨床兒科雜誌
림상인과잡지
2014年
4期
392-395
,共4页
紫癜性肾炎%治疗%儿童
紫癜性腎炎%治療%兒童
자전성신염%치료%인동
Henoch-Sch?ulen purpura nephritis%treatment%child
紫癜性肾炎是最常见的儿童继发性肾小球疾病。其临床表现不一，轻者仅表现为镜下血尿、微量蛋白尿，重者可逐渐进展为肾功能不全，直至终末期肾脏病而需要依靠长期肾脏替代治疗，严重影响患儿生存质量。近年来过敏性紫癜发生率不断提高，需予以重视。关于紫癜性肾炎的治疗，目前国内外有较多的研究，但结果不尽一致，因此至今未有定论。我们提倡阶梯式疗法，即根据患儿临床表现、肾脏病理选择合适的方案，而对于重症紫癜性肾炎，我们推荐多药强化治疗并联合血浆置换等方法以缓解病情。
紫癜性腎炎是最常見的兒童繼髮性腎小毬疾病。其臨床錶現不一，輕者僅錶現為鏡下血尿、微量蛋白尿，重者可逐漸進展為腎功能不全，直至終末期腎髒病而需要依靠長期腎髒替代治療，嚴重影響患兒生存質量。近年來過敏性紫癜髮生率不斷提高，需予以重視。關于紫癜性腎炎的治療，目前國內外有較多的研究，但結果不儘一緻，因此至今未有定論。我們提倡階梯式療法，即根據患兒臨床錶現、腎髒病理選擇閤適的方案，而對于重癥紫癜性腎炎，我們推薦多藥彊化治療併聯閤血漿置換等方法以緩解病情。
자전성신염시최상견적인동계발성신소구질병。기림상표현불일，경자부표현위경하혈뇨、미량단백뇨，중자가축점진전위신공능불전，직지종말기신장병이수요의고장기신장체대치료，엄중영향환인생존질량。근년래과민성자전발생솔불단제고，수여이중시。관우자전성신염적치료，목전국내외유교다적연구，단결과불진일치，인차지금미유정론。아문제창계제식요법，즉근거환인림상표현、신장병리선택합괄적방안，이대우중증자전성신염，아문추천다약강화치료병연합혈장치환등방법이완해병정。
Henoch-Sch?nlein purpura nephritis (HSPN) is the most common secondary glomerular disease in children. The clinical manifestations of HSPN vary from microscopic hematuria, microalbuminuria to renal dysfunction even end stage renal disease which is needed to rely on long-term renal replacement therapy, thus affecting the quality of children life seriously. In recent years, the incidence of Henoch-Sch?nlein purpura continues to increase, which should be paid more attention. There are many studies about the treatment of HSPN both at home and abroad, yet no certain conclusion is drawn because of the inconsistent results. We advocate stepped therapies, that is, the appropriate regimens are chosen based on the clinical manifestations and renal pathology in children. For severe HSPN, we recommend multi-drug intensive therapy combined with other methods such as plasma exchange to alleviate the symptoms.
