CAJ | 학술논문

目的：观察乳铁蛋白联合幽门螺杆菌（H.pylori）标准三联疗法对儿童H.pylori感染根除率的影响及其不良反应。方法将2012年1月至2013年1月确诊且未接受过根除治疗的H.pylori感染患儿90例随机分为两组，对照组45例接受标准三联疗法治疗，观察组45例在接受标准三联疗法同时联合应用乳铁蛋白，记录治疗过程中的不良反应，以及疗程结束后4周的H.pylori根除率。结果观察组H.pylori根除率为（91.11%，41/45），高于对照组的根除率（73.33%，33/45）；观察组不良反应率为（4.44%，2/45），低于对照组的不良反应率（20.00%，9/45），差异均有统计学意义（P均<0.05）。结论乳铁蛋白能提高H.pylori根除率，减少不良反应的发生。
목적：관찰유철단백연합유문라간균（H.pylori）표준삼련요법대인동H.pylori감염근제솔적영향급기불량반응。방법장2012년1월지2013년1월학진차미접수과근제치료적H.pylori감염환인90례수궤분위량조，대조조45례접수표준삼련요법치료，관찰조45례재접수표준삼련요법동시연합응용유철단백，기록치료과정중적불량반응，이급료정결속후4주적H.pylori근제솔。결과관찰조H.pylori근제솔위（91.11%，41/45），고우대조조적근제솔（73.33%，33/45）；관찰조불량반응솔위（4.44%，2/45），저우대조조적불량반응솔（20.00%，9/45），차이균유통계학의의（P균<0.05）。결론유철단백능제고H.pylori근제솔，감소불량반응적발생。
Objective To observe the effect of lactoferrin supplementation combined with standard triple therapy on eradication rate of Helicobacter pylori (H.pylori) and its adverse reaction in children. Methods A total of 90 children who were diagnosed with H.pylori infection from January 2012 to January 2013 and had never received eradicative treatment were ran-domly divided into two groups. Forty-five children in control group received the standard triple therapy and another 45 children in observation group received lactoferrin supplementation combined with standard triple therapy. Adverse reaction during the treatment was recorded and eradication rate of H.pylori at 4 weeks after treatment was observed. Results The eradication rate of H.pylori in observation group (91.11%, 41/45) was higher than that in control group (73.33%, 33/45) and the adverse reaction rate in observation group (4.44%, 2/45) was lower than that in control group (20.00%, 9/45).The differences were significant (P<0.05). Conclusions Lactoferrin supplementation combined with standard triple therapy can increase H.pylori eradication rate and reduce the occurrence of adverse reaction.