CAJ | 학술논문

血管紧张素Ⅱ( AngⅡ)是肾素-血管紧张素系统中的主要的多功能活性肽,其基本功能是调节血压和水、盐代谢平衡。然而,近年来的研究发现,AngⅡ作为一种潜在的生长因子,通过作用于其1型受体( AT1R)在肿瘤生长及血管生成中发挥着非常重要的作用。该文就近年来 AngⅡ-AT1R系统在肿瘤血管生成中的作用研究作一概述。
혈관긴장소Ⅱ( AngⅡ)시신소-혈관긴장소계통중적주요적다공능활성태,기기본공능시조절혈압화수、염대사평형。연이,근년래적연구발현,AngⅡ작위일충잠재적생장인자,통과작용우기1형수체( AT1R)재종류생장급혈관생성중발휘착비상중요적작용。해문취근년래 AngⅡ-AT1R계통재종류혈관생성중적작용연구작일개술。
AngiotensinⅡ( AngⅡ) is the main functional bioac-tive peptide of the renin angiotensin system,and its basic function is to regulate salt-water homeostasis and blood pressure. Howev-er,recent studies have shown that AngⅡ plays a very important role in tumor formation and angiogenesis by acting on its type 1 receptor (AT1R) as a kind of potential growth factor. This arti-cle is a brief overview of the research on effects of AngⅡ-AT1R system in the process of tumor angiogenesis in recent years.