CAJ | 학술논문

回顾性分析1998年1月至2012年12月间在中国医学科学院肿瘤医院腹部外科接受根治性手术，且临床资料完整和术后随访资料完整的147例壶腹癌患者的临床资料。低中性粒细胞/淋巴细胞比值（NLR）组（NLR＜5，121例）5年无病生存率为57.9％，高NLR组（NLR≥5，26例）为27.6％，两者差异有统计学意义（ P＝0.005）；单因素分析肿瘤分化（ P＝0.008）、淋巴结转移（ P＝0.008）、侵犯胰腺（P＝0.002）、肿瘤侵犯深度（P＝0.006）、肿瘤分期（P＝0.003）、术前NLR（P＝0.005）为壶腹癌的预后影响因素；多因素分析术前NLR是影响本组壶腹癌预后的独立危险因素（P＜0.05）。表明NLR作为壶腹癌预后评价指标具有重要的价值。
회고성분석1998년1월지2012년12월간재중국의학과학원종류의원복부외과접수근치성수술，차림상자료완정화술후수방자료완정적147례호복암환자적림상자료。저중성립세포/림파세포비치（NLR）조（NLR＜5，121례）5년무병생존솔위57.9％，고NLR조（NLR≥5，26례）위27.6％，량자차이유통계학의의（ P＝0.005）；단인소분석종류분화（ P＝0.008）、림파결전이（ P＝0.008）、침범이선（P＝0.002）、종류침범심도（P＝0.006）、종류분기（P＝0.003）、술전NLR（P＝0.005）위호복암적예후영향인소；다인소분석술전NLR시영향본조호복암예후적독립위험인소（P＜0.05）。표명NLR작위호복암예후평개지표구유중요적개치。
The clinical data of 147 patients with carcinoma of ampulla of Vatar at our hospital from January 1998 to December 2012 were retrospectively analyzed.The neutrophil-to-lymphocyte ratio ( NLR) was calculated from pre-operative complete blood count.They were divided into low NLR group (NLR<5,n=121) and high NLR group (NLR≥5,n=26).The 5-year survival rates of two groups were compared and the prognostic risk factors examined by univariate analysis and Cox model.The 5-year free survival rates of low and high NLR groups were 57.9%and 27.6%respectively ( P=0.005 ).Univariate analysis revealed that depth of invasion (P=0.006),pancreatic invasion (P=0.002),lymph nodal metastasis (P=0.008), poor differentiation ( P =0.008 ) , tumor stage ( P =0.003 ) and per-operative NLR ( P =0.005 ) were significant prognostic factors.Multivariate analysis showed that per-operative NLR significantly increased the risk of recurrence (P<0.05).Pre-operative NLR represents a significant independent prognostic indicator for patients with carcinoma of ampulla of Vatar.