中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
5期
709-712
,共4页
蔡欣蕊%钱卫斌%钱秋海%姜群群%冯晓
蔡訢蕊%錢衛斌%錢鞦海%薑群群%馮曉
채흔예%전위빈%전추해%강군군%풍효
糖肾宁%糖尿病肾病大鼠模型%RT-PCR:凝集素样氧化型低密度脂蛋白受体
糖腎寧%糖尿病腎病大鼠模型%RT-PCR:凝集素樣氧化型低密度脂蛋白受體
당신저%당뇨병신병대서모형%RT-PCR:응집소양양화형저밀도지단백수체
Tangshenning%Early diabetic nephropathy rats model%RT-PCR%LOX-1
目的:观察糖肾宁对糖尿病肾病模型大鼠早期肾功能及肾脏组织中LOX-1mRNA表达的影响。方法:用三联造模法(单侧肾摘除+高糖高脂+小剂量链脲佐菌素腹腔注射)建立早期糖尿病肾病大鼠模型,糖肾宁干预12周后,采用RT-PCR方法观察大鼠肾脏组织中LOX-1mRNA表达的变化。结果:用三联造模法可成功复制早期糖尿病肾病大鼠模型,模型大鼠的肾脏组织中LOX-1mRNA表达增多,糖肾宁可减少LOX-1mRNA在模型大鼠肾脏组织中的异常表达。结论:LOX-1的异常表达是糖尿病肾病的发病机制之一,糖肾宁可能通过降低LOX-1mRNA在模型大鼠肾脏组织中的异常表达对肾功能起到保护作用,值得进一步深入研究。
目的:觀察糖腎寧對糖尿病腎病模型大鼠早期腎功能及腎髒組織中LOX-1mRNA錶達的影響。方法:用三聯造模法(單側腎摘除+高糖高脂+小劑量鏈脲佐菌素腹腔註射)建立早期糖尿病腎病大鼠模型,糖腎寧榦預12週後,採用RT-PCR方法觀察大鼠腎髒組織中LOX-1mRNA錶達的變化。結果:用三聯造模法可成功複製早期糖尿病腎病大鼠模型,模型大鼠的腎髒組織中LOX-1mRNA錶達增多,糖腎寧可減少LOX-1mRNA在模型大鼠腎髒組織中的異常錶達。結論:LOX-1的異常錶達是糖尿病腎病的髮病機製之一,糖腎寧可能通過降低LOX-1mRNA在模型大鼠腎髒組織中的異常錶達對腎功能起到保護作用,值得進一步深入研究。
목적:관찰당신저대당뇨병신병모형대서조기신공능급신장조직중LOX-1mRNA표체적영향。방법:용삼련조모법(단측신적제+고당고지+소제량련뇨좌균소복강주사)건립조기당뇨병신병대서모형,당신저간예12주후,채용RT-PCR방법관찰대서신장조직중LOX-1mRNA표체적변화。결과:용삼련조모법가성공복제조기당뇨병신병대서모형,모형대서적신장조직중LOX-1mRNA표체증다,당신저가감소LOX-1mRNA재모형대서신장조직중적이상표체。결론:LOX-1적이상표체시당뇨병신병적발병궤제지일,당신저가능통과강저LOX-1mRNA재모형대서신장조직중적이상표체대신공능기도보호작용,치득진일보심입연구。
Objective:To observe the effect of Tangshenning on renal function and LOX-1 mRNA expression in the kidney of early diabetic nephropathy rats model. Methods:Early diabetic nephropathy rats model was made with high fat diet, STZ and unilateral ne-phregtomy. After the 12-week drug intervention, the rats were sacrificed, the kidneys were removed and the mRNA expressions of LOX-1 in the kidney were observed by the method of RT-PCR. Results:Early diabetic nephropathy rats model was successfully made by the triple-modeling method. The mRNA expression of LOX-1 in the kidney was significantly increased, and Tangshenning could low-er the expression of LOX-1 in the kidney in a dose-dependent manner. Conclusion:The abnormal expression of LOX-1 could be one of the mechanisms for diabetic nephropathy. Tangshening has good kidney protective effect through decreasing LOX-1 abnormal expression in the kidneys, which deserves further research.