CAJ | 학술논문

近年来研究发现，靶向于特异表位的多肽药物治疗自身免疫病，可避免传统药物的非特异性免疫抑制，在自身免疫病动物模型及临床试验中显示出较好的治疗效果。该文从抑制自身免疫反应的候选多肽来源及其作用机制等方面，综述了近年来治疗自身免疫病多肽药物的研究进展和趋势，为全面深入了解自身免疫病免疫耐受机制及寻求新的治疗方法提供理论依据。
근년래연구발현，파향우특이표위적다태약물치료자신면역병，가피면전통약물적비특이성면역억제，재자신면역병동물모형급림상시험중현시출교호적치료효과。해문종억제자신면역반응적후선다태래원급기작용궤제등방면，종술료근년래치료자신면역병다태약물적연구진전화추세，위전면심입료해자신면역병면역내수궤제급심구신적치료방법제공이론의거。
Recent studies have found that peptide therapies tar-geting specific epitopes can avoid nonspecific immune suppres-sion induced by traditional medicines for the treatment of autoim-mune diseases, and have shown great therapeutic effect in ani-mal models of autoimmune diseases and clinical trials. The pa-per summaries the research progress and trends of peptide drugs for the treatment of autoimmune diseases from candidate peptide sources and their suppression mechanisms, which can provide a theoretical basis for the in-depth understanding of immune toler-ance and allow for discovery of new treatment for autoimmune diseases.