CAJ | 학술논문

目的：观察红景天苷体内抗肿瘤作用,初步探讨其可能机制。方法建立荷瘤小鼠模型,实验分为5组,即红景天苷低、中、高剂量组,NS组及苦参碱对照组；ip给药8 d,观察小鼠肿瘤生长情况及生存时间,测定抑瘤率、生命延长率、脾脏系数以及血清IL-2、IL-12水平等指标。结果红景天苷能明显改善荷瘤小鼠一般状况；红景天苷低、中、高3个剂量组均有抑瘤作用( P<0．01),抑瘤率分别为28．9%、43．3%、53．5%；红景天苷各剂量组均能延长小鼠的生存时间( P<0．01),生命延长率分别为37．54%、48．96%、52．85%；红景天苷各剂量组小鼠脾脏系数与血清IL-2、IL-12水平均明显高于NS组与苦参碱组。结论红景天苷具有明显的抗肿瘤作用,其机制可能与提高机体免疫功能有关。
목적：관찰홍경천감체내항종류작용,초보탐토기가능궤제。방법건립하류소서모형,실험분위5조,즉홍경천감저、중、고제량조,NS조급고삼감대조조；ip급약8 d,관찰소서종류생장정황급생존시간,측정억류솔、생명연장솔、비장계수이급혈청IL-2、IL-12수평등지표。결과홍경천감능명현개선하류소서일반상황；홍경천감저、중、고3개제량조균유억류작용( P<0．01),억류솔분별위28．9%、43．3%、53．5%；홍경천감각제량조균능연장소서적생존시간( P<0．01),생명연장솔분별위37．54%、48．96%、52．85%；홍경천감각제량조소서비장계수여혈청IL-2、IL-12수평균명현고우NS조여고삼감조。결론홍경천감구유명현적항종류작용,기궤제가능여제고궤체면역공능유관。
Aim To investigate the inhibitory effect of salidroside on tumor growth in tumor-bearing mice and explore its possible mechanisms of anti-tumor action in vivo. Methods The tumor-bearing mice model was established, and the mice were randomly divided into five experimantal groups, including the salidroside low, medium and high doses groups, NS group and positive control matrine group. After continuous injec-tion of drug for eight days, the tumor growth and sur-vival time were measured, tumor growth inhibition rate and life extension rate, spleen index,the content of se-rum IL-2 and IL-12 were calculated. Results The general situation of the salidroside mice was better than the NS group and the positive control matrine group. Compared with NS group, the salidroside low,medium and high doses groups showed inhibitory effects on H22 solid tumor ( P<0. 01 ) with inhibition ratio 28. 9 %, 43. 3 % and 53. 5 %,and lengthened the survival time of mice ( P<0. 01 ) with the life extension rate 37. 54%,48. 96 % and 52. 85 % respectively. The spleen index and the content of serum IL-2 and IL-12 of the salidroside mice were significantly higher than NS group and matrine group. Conclusion Salidroside has marked inhibitory effects on tumor growth in vivo, its mechanism is probably related to improving the anti-tumor immune function.