CAJ | 학술논문

目的：探讨首次发病住院苯丙胺类兴奋剂（ATS）所致精神障碍患者的认知功能特点及其影响因素。方法：采用韦氏记忆量表（WMS-RC）、连续操作测验（CPT）、威斯康星卡片分类测验（WCST）评定80例首发 ATS 所致精神障碍患者（研究组）和80名健康人（对照组）的认知功能；采用简明精神病量表（BPRS）评定患者病情严重程度。对影响神经心理学测验成绩与 BPRS 进行逐步多元回归分析。结果：研究组 WCST 中的总应答数、持续错误数、随机错误数显著高于对照组（F ＝10.87~68.78，P ﹤0.01或 P ﹤0.001）；正确应答数、完成分类数、记忆商数、数字累加、短时记忆、瞬时记忆、连续操作测验正确数均显著低于对照组（F ＝4.92~114.20，P ﹤0.02或 P ﹤0.001）。研究组总应答数和持续错误数与BPRS 总分呈正相关（β＝0.26，P ＝0.01；β＝0.20，P ＝0.02）；随机错误数与敌对猜疑分呈正相关（β＝0.23，P ＝0.02）；正确应答数与思维障碍分呈负相关（β＝-0.22，P ＝0.01）；完成分类数与缺乏活力分呈负相关（β＝-0.22；P ＝0.01）；记忆商数和长时记忆与焦虑忧郁分呈负相关（β＝-0.32，P ＝0.00；β＝-0.22，P ＝0.00）；短时记忆和瞬时记忆与缺乏活力分呈负相关（β＝-0.36，P ＝0.00；β＝-0.32，P ＝0.00）；CPT 正确数与 BPRS 总分呈负相关（β＝-0.34，P ＝0.00）。结论：首发 ATS 所致精神障碍患者的记忆、注意和执行功能等明显减退，临床症状严重程度越大，认知功能损害越大。
목적：탐토수차발병주원분병알류흥강제（ATS）소치정신장애환자적인지공능특점급기영향인소。방법：채용위씨기억량표（WMS-RC）、련속조작측험（CPT）、위사강성잡편분류측험（WCST）평정80례수발 ATS 소치정신장애환자（연구조）화80명건강인（대조조）적인지공능；채용간명정신병량표（BPRS）평정환자병정엄중정도。대영향신경심이학측험성적여 BPRS 진행축보다원회귀분석。결과：연구조 WCST 중적총응답수、지속착오수、수궤착오수현저고우대조조（F ＝10.87~68.78，P ﹤0.01혹 P ﹤0.001）；정학응답수、완성분류수、기억상수、수자루가、단시기억、순시기억、련속조작측험정학수균현저저우대조조（F ＝4.92~114.20，P ﹤0.02혹 P ﹤0.001）。연구조총응답수화지속착오수여BPRS 총분정정상관（β＝0.26，P ＝0.01；β＝0.20，P ＝0.02）；수궤착오수여활대시의분정정상관（β＝0.23，P ＝0.02）；정학응답수여사유장애분정부상관（β＝-0.22，P ＝0.01）；완성분류수여결핍활력분정부상관（β＝-0.22；P ＝0.01）；기억상수화장시기억여초필우욱분정부상관（β＝-0.32，P ＝0.00；β＝-0.22，P ＝0.00）；단시기억화순시기억여결핍활력분정부상관（β＝-0.36，P ＝0.00；β＝-0.32，P ＝0.00）；CPT 정학수여 BPRS 총분정부상관（β＝-0.34，P ＝0.00）。결론：수발 ATS 소치정신장애환자적기억、주의화집행공능등명현감퇴，림상증상엄중정도월대，인지공능손해월대。
Objective:To explore the cognition function features and the affecting factors in patients with first-episode mental disorders caused by amphetamine-type stimulants(ATS). Method:Eighty mental disorder patients caused by ATS(study group)and 80 healthy controls(control group)were involved. The cognitive func-tion was measured with a series of neuropsychological test,and the illness severity assessed with the brief psychiat-ric rating scale(BPRS). Results:The scores of total responses,preservative errors,random errors in WCST in research group were higher than those in control group(F =10. 87 -68. 78;P ﹤0. 01 or P ﹤0. 001). However,the scores of correct responses,number of categories completed,memory quotient,numeric accumulation,short-term and instantaneous memory,continuous performance test(CPT)correct number were significantly lower than those in control group(F =4. 92 -114. 20;P ﹤0. 02 or P ﹤0. 001). The research group total responses and preservative errors were positively correlated to the BPRS total score(β =0. 26,P = 0. 01;β = 0. 20,P = 0. 02),random errors were positively correlated to hostile suspicion score(β =0. 23,P =0. 02),correct responses were negatively corre-lated to thought disorder score(β = -0. 22,P =0. 01),number of categories completed were negatively correlated to lack of energy score(β = -0. 22,P =0. 01),memory quotient and long-term memory were negatively correlated to anxiety depression score(β = -0. 32,P =0. 00;β = -0. 22,P = 0. 00),short-term and instantaneous memories were negatively correlated to lack of energy score(β = - 0. 36,P = 0. 00;β = - 0. 32,P = 0. 00),CPT correct number was negatively correlated to BPRS total score(β = - 0. 34,P = 0. 00). Conclusion:The paitents with first-episode mental disorders caused by ATS have obvious impairments in memory,attention and execute function. The more severe the clinical symptoms is ,the greater the impairment on the cognitive function is.