CAJ | 학술논문

目的：探讨双相情感障碍 I 型患者认知功能的损害特点。方法：纳入66例缓解期双相情感障碍 I 型患者和66名正常对照者，随访1年，分别采用数字符号、数字广度（顺背、倒背）、连线测验 A （TMT-A）、连线测验 B（TMT-B）和威斯康星卡片分类测验（WCST）评定，比较基线和1年后认知功能的变化。两次评定时要求患者均处于缓解期。结果：①患者组数字符号、数字广度（顺背、倒背）、TMT-A、TMT-B 和 WSCT（总错误数和持续错误数）成绩均差于正常对照组（P 均﹤0.01），1年后这种损害持续存在，并且保持稳定不变（P ﹥0.02）。②患者组顺背、倒背、TMT-A 和数字符号均与病程显著相关（P ﹤0.02或 P ﹤0.01），患者组顺背、TMT-A 和数字符号均与职业情况显著相关（P ﹤0.02或 P ﹤0.01），未发现任何认知功能指标与发病年龄和缓解时间相关（P ﹥0.02）。结论：双相情感障碍 I 型患者病情缓解后仍存在明显的注意、记忆和执行功能损害，并且这种损害1年后持续存在，无进一步恶化。
목적：탐토쌍상정감장애 I 형환자인지공능적손해특점。방법：납입66례완해기쌍상정감장애 I 형환자화66명정상대조자，수방1년，분별채용수자부호、수자엄도（순배、도배）、련선측험 A （TMT-A）、련선측험 B（TMT-B）화위사강성잡편분류측험（WCST）평정，비교기선화1년후인지공능적변화。량차평정시요구환자균처우완해기。결과：①환자조수자부호、수자엄도（순배、도배）、TMT-A、TMT-B 화 WSCT（총착오수화지속착오수）성적균차우정상대조조（P 균﹤0.01），1년후저충손해지속존재，병차보지은정불변（P ﹥0.02）。②환자조순배、도배、TMT-A 화수자부호균여병정현저상관（P ﹤0.02혹 P ﹤0.01），환자조순배、TMT-A 화수자부호균여직업정황현저상관（P ﹤0.02혹 P ﹤0.01），미발현임하인지공능지표여발병년령화완해시간상관（P ﹥0.02）。결론：쌍상정감장애 I 형환자병정완해후잉존재명현적주의、기억화집행공능손해，병차저충손해1년후지속존재，무진일보악화。
Objective:To explore the characteristic of the impairment of cognitive function in patients with bipolar I disorder(BD-I). Method:Sixty-six euthymic patients with BD-I and 66 healthy-matched con-trols were cognitively assessed twice over a 1-year follow-up. The patients were in euthymic during the both eval-uations. Cognitive assessment were performed by using digit symbol,digit span,trail making test( TMT)and Wisconsin card sorting test(WSCT). Results:①The results of digit symbol,digit span,TMT and WSCT were significantly poorer in BD-I patients than in normal controls(all P ﹤ 0. 01). Such deficits were maintained over a 1-year period(P ﹥ 0. 02). ②In BD-I patients,digit span,TMT-A and digit symbol were significantly correlated with duration of illness(P ﹤ 0. 02 or P ﹤ 0. 01). Digit forward,TMT-A and digit symbol were significantly corre-lated with current job situation(P ﹤ 0. 02 or P ﹤ 0. 01). None of the indexes of cognitive function were signifi-cantly correlated with length of euthymia or the age of onset(P ﹥ 0. 02). Conclusion:Cognitive functions,in-cluding attention,memory and executive function are impaired in BD-I patients. This impairment is maintained but does not worsen over 1-year period.