济宁医学院学报
濟寧醫學院學報
제저의학원학보
JOURNAL OF JINING MEDICAL COLLEGE
2014年
2期
91-93,96
,共4页
徐清%周静萍%柳海
徐清%週靜萍%柳海
서청%주정평%류해
Ezrin蛋白%CD44v6%口腔鳞癌%免疫组织化学
Ezrin蛋白%CD44v6%口腔鱗癌%免疫組織化學
Ezrin단백%CD44v6%구강린암%면역조직화학
Ezrin%CD44v6%Oral squamous cell carcinoma%Immunohistochemistry
目的：研究Ezrin蛋白和CD44v6在口腔鳞癌中的表达和意义，探讨两者表达的相互关系。方法用免疫组织化学SP法检测Ezrin蛋白和CD44v6在39例口腔鳞癌和28例正常口腔黏膜中的表达。结果1） Ezrin蛋白和CD44v6在口腔鳞癌中的表达水平显著高于正常口腔黏膜组（P＜0．01或 P＜0．05）；2）Ezrin蛋白的表达水平随口腔鳞癌的病理分级增高而增高（ P＜0．01），CD44v6在口腔鳞癌各病理分级中的表达差异无统计学意义（P＞0．05）；3）在有淋巴结转移的口腔鳞癌中，Ezrin蛋白和CD44v6的表达水平高于无淋巴结转移组（P＜0．01或 P＜0．05）；4）Ezrin蛋白和CD44v6的表达水平与口腔鳞癌患者的年龄、性别无关（P＞0．05）；5）Ezrin蛋白和CD44v6在口腔鳞癌中的表达呈正相关（P＜0．01）。结论 Ezrin蛋白和CD44v6与口腔鳞癌的发生、发展和侵袭转移密切相关，联合检测Ezrin蛋白和CD44v6的表达可作为评估口腔鳞癌恶性程度及转移潜能的有效指标。
目的：研究Ezrin蛋白和CD44v6在口腔鱗癌中的錶達和意義，探討兩者錶達的相互關繫。方法用免疫組織化學SP法檢測Ezrin蛋白和CD44v6在39例口腔鱗癌和28例正常口腔黏膜中的錶達。結果1） Ezrin蛋白和CD44v6在口腔鱗癌中的錶達水平顯著高于正常口腔黏膜組（P＜0．01或 P＜0．05）；2）Ezrin蛋白的錶達水平隨口腔鱗癌的病理分級增高而增高（ P＜0．01），CD44v6在口腔鱗癌各病理分級中的錶達差異無統計學意義（P＞0．05）；3）在有淋巴結轉移的口腔鱗癌中，Ezrin蛋白和CD44v6的錶達水平高于無淋巴結轉移組（P＜0．01或 P＜0．05）；4）Ezrin蛋白和CD44v6的錶達水平與口腔鱗癌患者的年齡、性彆無關（P＞0．05）；5）Ezrin蛋白和CD44v6在口腔鱗癌中的錶達呈正相關（P＜0．01）。結論 Ezrin蛋白和CD44v6與口腔鱗癌的髮生、髮展和侵襲轉移密切相關，聯閤檢測Ezrin蛋白和CD44v6的錶達可作為評估口腔鱗癌噁性程度及轉移潛能的有效指標。
목적：연구Ezrin단백화CD44v6재구강린암중적표체화의의，탐토량자표체적상호관계。방법용면역조직화학SP법검측Ezrin단백화CD44v6재39례구강린암화28례정상구강점막중적표체。결과1） Ezrin단백화CD44v6재구강린암중적표체수평현저고우정상구강점막조（P＜0．01혹 P＜0．05）；2）Ezrin단백적표체수평수구강린암적병리분급증고이증고（ P＜0．01），CD44v6재구강린암각병리분급중적표체차이무통계학의의（P＞0．05）；3）재유림파결전이적구강린암중，Ezrin단백화CD44v6적표체수평고우무림파결전이조（P＜0．01혹 P＜0．05）；4）Ezrin단백화CD44v6적표체수평여구강린암환자적년령、성별무관（P＞0．05）；5）Ezrin단백화CD44v6재구강린암중적표체정정상관（P＜0．01）。결론 Ezrin단백화CD44v6여구강린암적발생、발전화침습전이밀절상관，연합검측Ezrin단백화CD44v6적표체가작위평고구강린암악성정도급전이잠능적유효지표。
Ob j ective To research the expression and significancy of Ezrin Protein and CD 44v6 in oral squamous cell carcinoma(OSCC) ,and discuss their expressive correlation .Methods To detect the expression of Ezrin Protein and CD44v6 in 39 cases of OSCC and 28 cases of normal oral mucosa tissues by adopting immunohistochemical SP method .Results 1)The expression of Ezrin protein and CD44v6 in OSCC was higher than in normal oral mucous (P<0 .01 or P<0 .05) .2)The expression of Ezrin protein was up-regulated with increased pathological grade of OSCC (P<0 .01) .The differences of CD44v6 expression in various pathological grading of oral squamous cell carcinoma were not statistically significant (P>0 .05) .3)The expression of the Ezrin Protein and CD44v6 in OSCC with the lymph node metastasis was higher than that without the lymph node metastasis ( P<0 .01 or P<0 .05 ) .4 )The ex-pression of the Ezrin Protein and CD44v6 had nothing to do with the age and gender of OSCC patient (P>0 .05) .5) The expression of Ezrin protein and CD44v6 in OSCC were positively correlated(P<0 .01) .Conclusion There is a close relationship of Ezrin Protein and CD 44v6 with the happening ,development ,invasion and metastasis of oral squamous cell carcinoma(OSCC) .The joint examination of the expression of Ezrin Protein and CD 44v6 could be one effective index for the evaluation of grade malignancy and transferring proficiency for OSCC .
