浙江师范大学学报(自然科学版)
浙江師範大學學報(自然科學版)
절강사범대학학보(자연과학판)
JOURNAL OF ZHEJIANG NORMAL UNIVERSITY(NATURAL SCIENCES)
2014年
2期
212-218
,共7页
潘永娟%金晓琴%刘伟娜%徐玲玲%杨莉
潘永娟%金曉琴%劉偉娜%徐玲玲%楊莉
반영연%금효금%류위나%서령령%양리
抗细胞凋亡蛋白%程序性细胞死亡%寡聚糖转移酶%N-糖基化%生物学功能
抗細胞凋亡蛋白%程序性細胞死亡%寡聚糖轉移酶%N-糖基化%生物學功能
항세포조망단백%정서성세포사망%과취당전이매%N-당기화%생물학공능
defender against cell death(DAD)%programmed cell death(PCD)%oligosaccharyltransferase (OST)%N-linked glycosylation%biological functions
结合国内外的研究,从抗细胞凋亡基因 DAD(defender against cell death)的发现、核苷酸序列同源性、表达特性和蛋白结构与功能等方面,对近年来 DAD 蛋白的研究进展进行了综述。 DAD 作为寡聚糖转移酶(ol-igosaccharyltransferase,OST)的亚基组分,参与了内质网( endoplasmic reticulum,ER)中蛋白质的 N-糖基化修饰,抑制程序性细胞死亡,与动植物的生长发育及多种生理与病理过程密切相关。
結閤國內外的研究,從抗細胞凋亡基因 DAD(defender against cell death)的髮現、覈苷痠序列同源性、錶達特性和蛋白結構與功能等方麵,對近年來 DAD 蛋白的研究進展進行瞭綜述。 DAD 作為寡聚糖轉移酶(ol-igosaccharyltransferase,OST)的亞基組分,參與瞭內質網( endoplasmic reticulum,ER)中蛋白質的 N-糖基化脩飾,抑製程序性細胞死亡,與動植物的生長髮育及多種生理與病理過程密切相關。
결합국내외적연구,종항세포조망기인 DAD(defender against cell death)적발현、핵감산서렬동원성、표체특성화단백결구여공능등방면,대근년래 DAD 단백적연구진전진행료종술。 DAD 작위과취당전이매(ol-igosaccharyltransferase,OST)적아기조분,삼여료내질망( endoplasmic reticulum,ER)중단백질적 N-당기화수식,억제정서성세포사망,여동식물적생장발육급다충생리여병리과정밀절상관。
It was overviewed the composition of the discovery,nucleotide and protein sequence homology,ex-pression characteristics,protein structures and functions of DAD. As an essential subunit of oligosaccharyl-transferase,defender against cell death(DAD)protein was well-known as one of negative regulators of PCD, involved in N-glycan modification,as well as related to physiological and pathological processes in plants and animals.