CAJ | 학술논문

目的：探讨高密度脂蛋白胆固醇（HDL-C）、超氧化物歧化酶（SOD）、游离脂肪酸（NEFA）水平与急性冠脉综合征（ACS）的相关性。方法：选择384例 ACS 患者为研究组，并选择同期住院的冠状动脉造影示无冠状动脉狭窄的285例非冠心病患者作为对照组，比较两组患者的 HDL-C、SOD、NEFA。结果：与对照组比较，研究组 HDL-C 和SOD水平显著降低（P ＜0．001），NEFA水平显著升高（P ＜0．001）；研究组中 HDL-C、SOD、NEFA水平均与冠状动脉病变严重程度相关。结论：ACS 患者的冠脉病变严重程度和心肌坏死的进展与 HDL-C、SOD、NEFA水平密切相关；HDL-C、SOD、NEFA水平的高低可作为预测心肌进一步损伤的重要指标，对冠心病的防治提供重要的临床依据。
목적：탐토고밀도지단백담고순（HDL-C）、초양화물기화매（SOD）、유리지방산（NEFA）수평여급성관맥종합정（ACS）적상관성。방법：선택384례 ACS 환자위연구조，병선택동기주원적관상동맥조영시무관상동맥협착적285례비관심병환자작위대조조，비교량조환자적 HDL-C、SOD、NEFA。결과：여대조조비교，연구조 HDL-C 화SOD수평현저강저（P ＜0．001），NEFA수평현저승고（P ＜0．001）；연구조중 HDL-C、SOD、NEFA수평균여관상동맥병변엄중정도상관。결론：ACS 환자적관맥병변엄중정도화심기배사적진전여 HDL-C、SOD、NEFA수평밀절상관；HDL-C、SOD、NEFA수평적고저가작위예측심기진일보손상적중요지표，대관심병적방치제공중요적림상의거。
Objective:To investigate the levels of high density lipoprotein cholesterol (HDL-C),super oxide dismutase(SOD) and non-esterified fatty acid(NEFA) in patients with acute coronary syndrome(ACS). Methods: A total of 384 patients with ACS diagnosed by coronary angiography were selected as research group , and 285 cases admitted to the hospital in the same period with normal coronary angiogram were selected as control group. The HDL-C,SOD and NEFA were compared between the two groups. Results: The levels of HDL-C and SOD in research group were significantly lower than those in control group(P < 0.001).The level of NEFA in research group was significantly higher than that in control group(P < 0.001). In research group, the levels of HDL-C ,SOD and NEFA were related to the severity of the coronary artery stenosis. Conclusion: There is a compact correlation between the severity of coronary artery disease and the progress of myocardial necrosis with the levels of HDL-C、SOD and NEFA in patients with ACS. The levels of HDL-C、SOD and NEFA can be the important indicators to predict the further damage of myocardial, they are provided important clinical evidence for prevention of coronary heart disease.