CAJ | 학술논문

目的：探讨氨磺必利与利培酮对精神分裂症患者催乳素及糖脂代谢的影响。方法：精神分裂症患者按治疗方案分为氨磺必利组（入组22例，完成20例）及利培酮组（入组20例，完成19例），分别在治疗前及治疗后4周、8周监测催乳素及糖脂代谢方面的各项指标，并分析治疗前后两组之间的差异。结果：两组治疗4周及治疗8周与治疗前相比，催乳素水平均有显著升高（P ﹤0.02）；利培酮组较氨磺必利组催乳素升高更为显著。两组胰岛素抵抗指数及体质量指数均升高（P ﹤0.02）。结论：与利培酮相比，氨磺必利对催乳素的影响相对较轻，而两种药物对代谢方面的影响相当。
목적：탐토안광필리여리배동대정신분렬증환자최유소급당지대사적영향。방법：정신분렬증환자안치료방안분위안광필리조（입조22례，완성20례）급리배동조（입조20례，완성19례），분별재치료전급치료후4주、8주감측최유소급당지대사방면적각항지표，병분석치료전후량조지간적차이。결과：량조치료4주급치료8주여치료전상비，최유소수평균유현저승고（P ﹤0.02）；리배동조교안광필리조최유소승고경위현저。량조이도소저항지수급체질량지수균승고（P ﹤0.02）。결론：여리배동상비，안광필리대최유소적영향상대교경，이량충약물대대사방면적영향상당。
Objective:To investigate the differences between the effect of amisulpride and risperidone on prolactin and metabolism in schizophrenic patients. Method:Fourty-five schizophrenic patients was divided into amisulpride group(22 cases enrolled,20 completed)and risperidone group(20 cases enrolled,19 comple-ted). Prolactin levels and various indictors of metabolism were detected before the treatment,4 weeks and 8 weeks after the treatment respectively. Results:Compared with baseline the serum prolactin levels in two groups,4 weeks and 8 weeks after the treatment increased significantly(P ﹤ 0. 02);but the prolactin of risperi-done group increased more significantly than amisulpride risperidone group. Insulin resistance and body mass in-dex were increased in both groups(P ﹤ 0. 02). Conclusion:Compared with risperidone,amisulpride has rela-tively less impact on prolactin,while two drugs had a similar impact on the metabolism.