CAJ | 학술논문

目的：研究双黄连粉针中3种主要有效成分的致类过敏反应性。方法：采用体内、外方法同时对双黄连粉针中的3种主要有效成分的致肥大细胞脱颗粒作用及组胺和类胰蛋白胰释放作用进行评价。结果：双黄连粉针中3种主要成分均未引起肥大细胞产生严重脱颗粒反应，组胺和类胰蛋白酶水平与生理盐水组相比亦无显著性差异。结论：双黄连粉针3种主要有效成分绿原酸、黄芩苷、连翘苷均不能引起实验动物的类过敏反应。
목적：연구쌍황련분침중3충주요유효성분적치류과민반응성。방법：채용체내、외방법동시대쌍황련분침중적3충주요유효성분적치비대세포탈과립작용급조알화류이단백이석방작용진행평개。결과：쌍황련분침중3충주요성분균미인기비대세포산생엄중탈과립반응，조알화류이단백매수평여생리염수조상비역무현저성차이。결론：쌍황련분침3충주요유효성분록원산、황금감、련교감균불능인기실험동물적류과민반응。
Objective:To study the anaphylactoid reaction of three effective components in Shuanghuanglian injection . Mehtod:Use in vivo and in vitro method for simultaneously three main effective components by mast cell degranulation and histamine and tryptase release effect evaluation of protein trypsin in Shuanghuanglian injection .Results:Mast cells produced serious degranulation responses and were not caused by three kinds of main components , histamine and tryptase levels compared with saline group also had no significant difference .Conclusion:Anaphylactoid reaction was not caused by three main effective components of Shuanghuanglian injection .