中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2012年
12期
1126-1130
,共5页
胡海洋%胡自力%王宏权%刘川%于圣杰
鬍海洋%鬍自力%王宏權%劉川%于聖傑
호해양%호자력%왕굉권%류천%우골걸
膀胱肿瘤%核蛋白质类%尿%细胞学诊断%Meta分析
膀胱腫瘤%覈蛋白質類%尿%細胞學診斷%Meta分析
방광종류%핵단백질류%뇨%세포학진단%Meta분석
Urinary bladder neoplasms%Nuclear proteins%Urine%Cytodiagnosis%Meta analysis
目的 系统评价核基质蛋白22(NMP22)和尿细胞学对膀胱癌诊断价值.方法 制定纳入、排除标准和检索策略,检索相关文献,根据纳入、排除标准筛选文献并评价质量和提取数据,用MetaDiSc 1.4进行meta分析.结果 共检索到相关文献266篇,排除256篇,对符合纳入标准的10篇文献行meta分析,共4895例.NMP22检测膀胱癌的总灵敏度为0.76(95％ CI:0.74～0.77)、总特异度为0.80(95％ CI:0.79 ～0.82)、总受试者工作特征曲线下面积(AUC)为0.8533；尿细胞学检测总灵敏度0.36(95％ CI:0.34～0.38),总特异度0.94(95％ CI:0.93～0.95),总受试者工作特征曲线下面积为0.8628.总诊断精确度Q*指数分别为0.7863和0.7934.结论 NMP22对膀胱癌诊断的灵敏度较尿细胞学明显增高,特异度比细胞学检测低,总体诊断效能中等,与尿细胞学无明显差异,目前不能取代尿细胞学检测.
目的 繫統評價覈基質蛋白22(NMP22)和尿細胞學對膀胱癌診斷價值.方法 製定納入、排除標準和檢索策略,檢索相關文獻,根據納入、排除標準篩選文獻併評價質量和提取數據,用MetaDiSc 1.4進行meta分析.結果 共檢索到相關文獻266篇,排除256篇,對符閤納入標準的10篇文獻行meta分析,共4895例.NMP22檢測膀胱癌的總靈敏度為0.76(95％ CI:0.74～0.77)、總特異度為0.80(95％ CI:0.79 ～0.82)、總受試者工作特徵麯線下麵積(AUC)為0.8533；尿細胞學檢測總靈敏度0.36(95％ CI:0.34～0.38),總特異度0.94(95％ CI:0.93～0.95),總受試者工作特徵麯線下麵積為0.8628.總診斷精確度Q*指數分彆為0.7863和0.7934.結論 NMP22對膀胱癌診斷的靈敏度較尿細胞學明顯增高,特異度比細胞學檢測低,總體診斷效能中等,與尿細胞學無明顯差異,目前不能取代尿細胞學檢測.
목적 계통평개핵기질단백22(NMP22)화뇨세포학대방광암진단개치.방법 제정납입、배제표준화검색책략,검색상관문헌,근거납입、배제표준사선문헌병평개질량화제취수거,용MetaDiSc 1.4진행meta분석.결과 공검색도상관문헌266편,배제256편,대부합납입표준적10편문헌행meta분석,공4895례.NMP22검측방광암적총령민도위0.76(95％ CI:0.74～0.77)、총특이도위0.80(95％ CI:0.79 ～0.82)、총수시자공작특정곡선하면적(AUC)위0.8533；뇨세포학검측총령민도0.36(95％ CI:0.34～0.38),총특이도0.94(95％ CI:0.93～0.95),총수시자공작특정곡선하면적위0.8628.총진단정학도Q*지수분별위0.7863화0.7934.결론 NMP22대방광암진단적령민도교뇨세포학명현증고,특이도비세포학검측저,총체진단효능중등,여뇨세포학무명현차이,목전불능취대뇨세포학검측.
Objective Systematic reviews of diagnostic value of the nuclear matrix protein 22 (NMP22) and urine cytology for bladder cancer.Methods Development of inclusion criteria,exclusion criteria and search strategy to retrieve relevant literature.Screening the literature according to inclusion criteria and exclusion criteria.Quality evaluation of the screening and data extraction,using MetaDiSc 1.4software for Meta analysis.Results In total,266 relevant studies were searched,exeluted 256 studies,and then 10 studies were included,with 4895 patients involved.The pooled sensitivity and specificity of NMP22 to detect bladder cancer were 0.76 (95％ CI:0.74-0.77),0.80 (95％ CI:0.79-0.82),respectively.The pooled sensitivity and specificity of urine cytology were 0.36 (95％ CI:0.34-0.38),0.94 (95％ CI:0.93-0.95),respectively.The area under curve (AUC) for NMP22 and urine cytology were 0.8533 and 0.8628,and Q * index were 0.7863 and 0.7934,respectively.Conclusions For the diagnosis of bladder cancer,the sensitivity of NMP22 was higher than urine cytology,but the specificity was lower than urine cytology.Overall diagnostic performance of NMP22 was medium,it was no significant difference with urine cytology.It cant replace urine cytology now.
