CAJ | 학술논문

【目的】调查和分析中年男性高脂血症患者伴发高同型半胱氨酸（Hcy ）血症、高铁蛋白（Ferr ）血症、高尿酸（U A ）血症发生情况。【方法】选取本院40～60岁男性高脂血症患者和同年龄段血脂正常者，经检查无肾病及近期未服用影响 Hcy、Ferr和UA代谢的药物，分别测定其体内 Hcy、Ferr及UA水平。【结果】①高脂血症组Hcy（15．83±5．79μmol/L）、Ferr（330±74ng/mL）、UA（380±90μmol/L）水平均高于血脂正常组 Hcy（8．58±4．26μmol/L）、Ferr（241±87ng/mL）、UA（325±86μmol/L）水平，且两组相比差异均有显著性（ P ＜0．01）。②高脂血症组高 Hcy血症发病率（21．3％）、高Ferr血症发病率（21．6％）、高UA血症发病率（36．5％）均高于血脂正常组高Hcy血症发病率（10．2％）、高Ferr血症发病率（8．1％）、高UA血症发病率（16．8％），且差异均具有显著性（ P＜0．01）。③不同年龄段之间对比：在高脂血症组和血脂正常组，50～60年龄段 Hcy水平均高于40～49年龄段（ P＜0．01），而高Hcy血症发病率在两个年龄段之间没有统计学差异（ P＞0．05）；Ferr水平、高Ferr血症发病率、UA水平和高UA血症发病率两个年龄段之间均没有统计学差异（ P＞0．05）。【结论】中年男性高脂血症者较之血脂正常者有较高的高 Hcy血症、高Ferr血症和高UA血症发病率，且Hcy与Ferr及UA水平也较高。监测这一特殊人群的 Hcy与Ferr及UA水平对指导临床有重要意义。
【목적】조사화분석중년남성고지혈증환자반발고동형반광안산（Hcy ）혈증、고철단백（Ferr ）혈증、고뇨산（U A ）혈증발생정황。【방법】선취본원40～60세남성고지혈증환자화동년령단혈지정상자，경검사무신병급근기미복용영향 Hcy、Ferr화UA대사적약물，분별측정기체내 Hcy、Ferr급UA수평。【결과】①고지혈증조Hcy（15．83±5．79μmol/L）、Ferr（330±74ng/mL）、UA（380±90μmol/L）수평균고우혈지정상조 Hcy（8．58±4．26μmol/L）、Ferr（241±87ng/mL）、UA（325±86μmol/L）수평，차량조상비차이균유현저성（ P ＜0．01）。②고지혈증조고 Hcy혈증발병솔（21．3％）、고Ferr혈증발병솔（21．6％）、고UA혈증발병솔（36．5％）균고우혈지정상조고Hcy혈증발병솔（10．2％）、고Ferr혈증발병솔（8．1％）、고UA혈증발병솔（16．8％），차차이균구유현저성（ P＜0．01）。③불동년령단지간대비：재고지혈증조화혈지정상조，50～60년령단 Hcy수평균고우40～49년령단（ P＜0．01），이고Hcy혈증발병솔재량개년령단지간몰유통계학차이（ P＞0．05）；Ferr수평、고Ferr혈증발병솔、UA수평화고UA혈증발병솔량개년령단지간균몰유통계학차이（ P＞0．05）。【결론】중년남성고지혈증자교지혈지정상자유교고적고 Hcy혈증、고Ferr혈증화고UA혈증발병솔，차Hcy여Ferr급UA수평야교고。감측저일특수인군적 Hcy여Ferr급UA수평대지도림상유중요의의。
[Objective]To investigate and analyze the prevalence of hyperhomocysteinemia ,hyperferriti-naemia and hyperuricemia in middle-aged male patients with hyperlipidemia .[Methods]Male patients(aged 40~60 years old) with hyperlipoidemia and subjects with normal blood lipid and the same age in our hospital were chosen .All patients had no nephrosis and recently had not taken drugs affecting the metabolism of homo-cysteine(Hcy) ,ferritin(Ferr) and uric acid(UA) .The levels of Hcy ,Ferr and UA were determined .[Re-sults] The levels of Hcy(15 .83 ± 5 .79μmol/L) ,Ferr(330 ± 74ng/ml) and UA(380 ± 90μmol/L) in hyperlipi-demia group were higher than those in normal group(8 .58 ± 4 .26μmol/L ,241 ± 87ng/ml and 325 ± 86μmol/L , respectively) ,and there was significant difference( P < 0 .01) .The morbidity of hyperhomocysteinemia(21 . 3% ) ,hyperferritinaemia(21 .6% ) and hyperuricemia(36 .5% ) in hyperlipidemia group were higher than those in normal group(10 .2% ,8 .1% and 16 .8% ,respectively) ,and there was significant difference( P <0 .01) . Different age groups were compared .Hcy level in 50~60 age group was higher than that in 40~49 age group ( P <0 .01) ,but there was no significant difference in the morbidity of hyperhomocysteinemia between these two age groups( P>0 .05) .There was no significant difference in the levels of Ferr and UA and the morbidity of hyperferritinaemia and hyperuricemia between these two age groups ( P > 0 .05) .[Conclusion] Compared with normal blood lipid group ,the morbidity of hyperhomocysteinemia ,hyperferritinaemia and hyperuricemia in middle-aged male patients with hyperlipidemia is higher ,and the levels of Hcy ,Ferr and UA are also high-er .It is important to monitor the levels of Hcy ,Ferr and UA in these special people for clinical practice .