CAJ | 학술논문

肠黏膜是构成动物体内与外界环境之间最大的接触表面，是易受病原体定植和入侵的最常见部位。肠黏膜免疫屏障作为保护动物机体免受外来病原微生物侵扰的重要防线，可在抗原的刺激下利用免疫细胞和免疫相关物质产生特异性免疫应答，同时可对无害抗原下调免疫反应或产生免疫耐受。研究肠黏膜免疫屏障功能作用的机制并通过人为保护性措施来预防和修复肠黏膜免疫功能损伤对于动物机体免疫屏障功能的正常发挥和生产实践具有重要意义。
장점막시구성동물체내여외계배경지간최대적접촉표면，시역수병원체정식화입침적최상견부위。장점막면역병장작위보호동물궤체면수외래병원미생물침우적중요방선，가재항원적자격하이용면역세포화면역상관물질산생특이성면역응답，동시가대무해항원하조면역반응혹산생면역내수。연구장점막면역병장공능작용적궤제병통과인위보호성조시래예방화수복장점막면역공능손상대우동물궤체면역병장공능적정상발휘화생산실천구유중요의의。
Gut mucosa constitutes the largest contact surface between the host and the external environment, and it is the most common site of colonization and invasion of susceptible pathogen.As an important line of de-fense protecting host against the infestation of foreign pathogenic microorganisms, gut mucosal immune barrier can take advantage of immune cells and immune-related material to produce specific immune responses stimula-ted by antigens.And it can down-regulate the immune responses or produce immune tolerance to harmless anti-gens.Research on mechanism of gut mucosal immune barrier and protective measures to prevent and recover impaired immune function can have great significance for normal immune barrier function normally and produc-tion practice.