中国中西医结合肾病杂志
中國中西醫結閤腎病雜誌
중국중서의결합신병잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN NEPHROLOGY
2014年
4期
318-320
,共3页
罗洋%龚勇%甘红兵%耿培宏
囉洋%龔勇%甘紅兵%耿培宏
라양%공용%감홍병%경배굉
睡眠呼吸暂停%阻塞性%呼吸暂停低通气指数%肾功能异常
睡眠呼吸暫停%阻塞性%呼吸暫停低通氣指數%腎功能異常
수면호흡잠정%조새성%호흡잠정저통기지수%신공능이상
Sleep apnea hypopnea%Obstructive%Apnea hypopnea index%Renal
目的:评价肾功能异常对阻塞性睡眠呼吸暂停低通气综合征( OSAHS)疾病进展的作用。方法:对2011年8月~2013年8月在首都医科大学附属北京天坛医院睡眠检测中心行睡眠呼吸监测的成人患者临床资料进行回顾性分析。结果:116例患者中。 OSAHS及非OSAHS分别为74例及42例。两组年龄、性别、糖尿病、高脂血症、高血压病及肾小球滤过率(eGFR)差异均存在统计学意义(P<0.05)。多因素 Logistic回归提示年龄(OR:2.6,95%CI:1.2~7.5)、肾功能异常(eGFR<60 ml·min-1·1.73 m-2)(OR:1.3,95%CI:1.1~10.2)、糖尿病(OR:3.5,95%CI:2.1~18.3)、肥胖(BMI>28)(OR:6.9,95%CI:3.1~28.1)及高三酰甘油血症(OR:1.7,95%CI:1.4~22.5)为 OSAHS 发生独立相关风险因素(P <0.05)。结论:肾功能异常是促进OSAHS发生的独立风险因素。
目的:評價腎功能異常對阻塞性睡眠呼吸暫停低通氣綜閤徵( OSAHS)疾病進展的作用。方法:對2011年8月~2013年8月在首都醫科大學附屬北京天罈醫院睡眠檢測中心行睡眠呼吸鑑測的成人患者臨床資料進行迴顧性分析。結果:116例患者中。 OSAHS及非OSAHS分彆為74例及42例。兩組年齡、性彆、糖尿病、高脂血癥、高血壓病及腎小毬濾過率(eGFR)差異均存在統計學意義(P<0.05)。多因素 Logistic迴歸提示年齡(OR:2.6,95%CI:1.2~7.5)、腎功能異常(eGFR<60 ml·min-1·1.73 m-2)(OR:1.3,95%CI:1.1~10.2)、糖尿病(OR:3.5,95%CI:2.1~18.3)、肥胖(BMI>28)(OR:6.9,95%CI:3.1~28.1)及高三酰甘油血癥(OR:1.7,95%CI:1.4~22.5)為 OSAHS 髮生獨立相關風險因素(P <0.05)。結論:腎功能異常是促進OSAHS髮生的獨立風險因素。
목적:평개신공능이상대조새성수면호흡잠정저통기종합정( OSAHS)질병진전적작용。방법:대2011년8월~2013년8월재수도의과대학부속북경천단의원수면검측중심행수면호흡감측적성인환자림상자료진행회고성분석。결과:116례환자중。 OSAHS급비OSAHS분별위74례급42례。량조년령、성별、당뇨병、고지혈증、고혈압병급신소구려과솔(eGFR)차이균존재통계학의의(P<0.05)。다인소 Logistic회귀제시년령(OR:2.6,95%CI:1.2~7.5)、신공능이상(eGFR<60 ml·min-1·1.73 m-2)(OR:1.3,95%CI:1.1~10.2)、당뇨병(OR:3.5,95%CI:2.1~18.3)、비반(BMI>28)(OR:6.9,95%CI:3.1~28.1)급고삼선감유혈증(OR:1.7,95%CI:1.4~22.5)위 OSAHS 발생독립상관풍험인소(P <0.05)。결론:신공능이상시촉진OSAHS발생적독립풍험인소。
Objective:To analysis the impact of renal dysfunction on the progression of obstructive apnea and hypopnea syn-drome ( OSAHS) . Methods:A retrospective study was performed among Chinese adult patients who were admitted polysomnography examination overnight. Patients were divided into OSAHS group (AHI≥5) and non-OSAHS group (AHI<5);multivariate Logistic regression analysis were performed to determine the risk factors of the incidence of OSAHS. Results:Overall ( total 116 patients inclu-ding 85 male and 31 female,median age was 60. 2 ± 19. 6 years old),74 patients were OSAHS and 42 were in non-OSAHA group. There were significant different in age,gender,hypertriglyceridemia ,lower estimated glomerular filtration rate ( eGFR<60 ml·min-1 ·1. 73 m-2),hypertension,diabetes and obesity among those different groups(P<0. 05). Logistic regression showed that age (OR:2.6,95%CI:1.2~7.5),renal dysfunction marked as lower eGFR (OR:1. 3,95%CI:1. 1 ~10. 2),diabetes (OR:3. 5,95%CI:2. 1~18. 3),obesity marked as BMI>28(OR:6. 9,95%CI:3. 1~28. 1),hypertriglyceridemia (OR:1. 7,95%CI:1. 4~22. 5) were significantly associated with the occurrence of OSAHS (P<0. 05). Conclusion:Renal dysfunction,together with age,diabetes,obesi-ty,hypertriglyceridemia are independent risk factors of the incidence of OSAHS.