CAJ | 학술논문

目的：观察代谢异常人群血清总胆碱酯酶（ CHE）的变化，探讨其在糖尿病、脂肪肝、超重发病发展中的作用和意义。方法收集来本院体检的人群，分为糖尿病、脂肪肝、超重组、糖尿病合并脂肪肝组和正常对照组，测定各组血清总胆碱酯酶水平。结果糖尿病、脂肪肝、超重组和糖尿病合并脂肪肝组的血清CHE水平均高于正常组[（依次为（8943±1896） U/L，（9716±1673）U/L，（8798±1710）U/L，（9385±1687）U/L vs （8028±1621）U/L]，脂肪肝组升高最显著。而糖尿病合并脂肪肝组的血清CHE水平与单纯糖尿病组或脂肪肝组差异均无统计学意义（ P ＞0.05）。有代谢综合征成分组的CHE均高于无代谢综合征成分组的患者[（8786±1514）U/L，（9141±1771）U/L，（9705±1628）U/L，（9138±1768）U/L，（9530±1607） U/L vs （7821±1324U/L]，但CHE并不是随着代谢综合征成分增多呈递增改变。血清CHE的水平与年龄呈负相关（ P ＝0.00），而与甘油三酯、总胆固醇、体质量指数呈正相关（ P ＝0.00）。结论血清胆碱酯酶在糖尿病、脂肪肝、超重等疾病中均升高，可能是其发病的危险因素，控制CHE水平对改善代谢疾病有一定的临床指导作用。
목적：관찰대사이상인군혈청총담감지매（ CHE）적변화，탐토기재당뇨병、지방간、초중발병발전중적작용화의의。방법수집래본원체검적인군，분위당뇨병、지방간、초중조、당뇨병합병지방간조화정상대조조，측정각조혈청총담감지매수평。결과당뇨병、지방간、초중조화당뇨병합병지방간조적혈청CHE수평균고우정상조[（의차위（8943±1896） U/L，（9716±1673）U/L，（8798±1710）U/L，（9385±1687）U/L vs （8028±1621）U/L]，지방간조승고최현저。이당뇨병합병지방간조적혈청CHE수평여단순당뇨병조혹지방간조차이균무통계학의의（ P ＞0.05）。유대사종합정성분조적CHE균고우무대사종합정성분조적환자[（8786±1514）U/L，（9141±1771）U/L，（9705±1628）U/L，（9138±1768）U/L，（9530±1607） U/L vs （7821±1324U/L]，단CHE병불시수착대사종합정성분증다정체증개변。혈청CHE적수평여년령정부상관（ P ＝0.00），이여감유삼지、총담고순、체질량지수정정상관（ P ＝0.00）。결론혈청담감지매재당뇨병、지방간、초중등질병중균승고，가능시기발병적위험인소，공제CHE수평대개선대사질병유일정적림상지도작용。
Objective To investigate the change of plasma cholinesterases (CHEs) in the people with diabetes or fatty liver or overweight , and explore the role of CHE in these diseases .Methods The plasma CHEs in 2834 subjects were detected , and these subjects were divided into five groups , including diabetes , fatty liver , overweight , diabetes with fatty liver , and the normal groups . Results The plasma CHE activities in diabetes group , fatty liver group , overweight group , and diabetes with fatty liver group were all higher than the normal group [(8943 ±1896)U/L, (9716 ±1673)U/L, (8798 ±1710)U/L, (9385 ±1687)U/L vs (8028 ±1621) U/L], and the CHE level in the fatty liver group was highest among five groups .However, the CHE level in diabetes group or fatty liv-er group was not significantly different from that in the diabetes with fatty liver group .The CHE level of the people with components of metabolic syndrome (MS) was significantly higher than that without MS component [(8786 ±1514)U/L, (9141 ±1771)U/L, (9705 ±1628)U/L, (9138 ±1768)U/L, (9530 ±1607)U/L vs (7821 ±1324)U/L]),but the CHE level was not increased gradually with the increased MS component.The plasma CHE had a negative correlation with age ( P =0.00),but it had a positive correlation with triglyceride (TG), total cholesterol (TC), and body mass index (BMI)( P =0.00).Conclusions The plasma CHE activity was el-evated in diabetes group , fatty liver group , and overweight group , which might be a risk factor in these diseases .Controlling the plas-ma CHE might help to treat the metabolism diseases .