CAJ | 학술논문

目的：探讨局部晚期宫颈癌组织中β-tubulin Ⅲ的表达及其在宫颈癌新辅助化疗中的意义。方法收集62例局部晚期宫颈癌患者肿瘤标本，采用免疫组化方法检测患者组织标本中β-tubulin Ⅲ的表达，并分析检测结果与宫颈癌临床病理特征的关系；按化疗方案分为两组，TP化疗组34例给予紫杉醇/顺铂（卡铂）方案化疗，PF化疗组28例给予5-氟尿嘧啶/顺铂方案化疗，2个疗程后评价疗效，分析TP方案和PF方案新辅助化疗后局部晚期宫颈癌的有效率及手术率，评估β-tubulinⅢ的表达在宫颈癌新辅助化疗中的意义。结果局部晚期宫颈癌组织中β-tubulinⅢ阳性表达率为62.90％；β-tubulinⅢ的表达与患者病理类型、分级及分期无关；β-tubulin Ⅲ的表达与TP方案化疗的有效率及手术率有关，β-tubulin Ⅲ阴性者化疗有效率和手术率分别为83.33％和83.33％，高于β-tubulinⅢ表达阳性者（59.09％，50.00％）（ P ＜0.05）；β-tubulinⅢ的表达与PF方案化疗的有效率和手术率无关（ P ＞0.05）；TP方案化疗的有效率及手术率高于PF方案化疗，但差异无统计学意义（ P ＞0.05）。结论在宫颈癌局部晚期新辅助化疗中，β-tubulin Ⅲ的表达情况可作为预测含紫杉醇联合化疗有效率和指导患者个体化化疗的重要指标。
목적：탐토국부만기궁경암조직중β-tubulin Ⅲ적표체급기재궁경암신보조화료중적의의。방법수집62례국부만기궁경암환자종류표본，채용면역조화방법검측환자조직표본중β-tubulin Ⅲ적표체，병분석검측결과여궁경암림상병리특정적관계；안화료방안분위량조，TP화료조34례급여자삼순/순박（잡박）방안화료，PF화료조28례급여5-불뇨밀정/순박방안화료，2개료정후평개료효，분석TP방안화PF방안신보조화료후국부만기궁경암적유효솔급수술솔，평고β-tubulinⅢ적표체재궁경암신보조화료중적의의。결과국부만기궁경암조직중β-tubulinⅢ양성표체솔위62.90％；β-tubulinⅢ적표체여환자병리류형、분급급분기무관；β-tubulin Ⅲ적표체여TP방안화료적유효솔급수술솔유관，β-tubulin Ⅲ음성자화료유효솔화수술솔분별위83.33％화83.33％，고우β-tubulinⅢ표체양성자（59.09％，50.00％）（ P ＜0.05）；β-tubulinⅢ적표체여PF방안화료적유효솔화수술솔무관（ P ＞0.05）；TP방안화료적유효솔급수술솔고우PF방안화료，단차이무통계학의의（ P ＞0.05）。결론재궁경암국부만기신보조화료중，β-tubulin Ⅲ적표체정황가작위예측함자삼순연합화료유효솔화지도환자개체화화료적중요지표。
Objective To investigate the β-tubulin Ⅲexpression in locally advanced cervical cancers and its significance in the neoadjuvant chemotherapy of cervical cancer .Methods Immunohistochemistry was used to detect the expression of β-tubulin Ⅲin tissue samples from 62 cases of locally advanced cervical cancer patients .Groups paclitaxel +cisplatin/carboplatin (TP) (34 pa-tients) underwent two cycles of TP chemotherapy ,while group 5-fluorouracil+cisplatin(PF) (28 patients) underwent two cycles of PF chemotherapy .Comprehensive analysis of β-tubulinⅢexpressions of TP and PF neoadjuvant chemotherapies revealed the efficien -cy and operation rate .Results The positive rate ofβ-tubulin Ⅲ was 62.90% in locally advanced cervical cancer .β-tubulin Ⅲ ex-pression was not correlated with clinicopathological features in locally advanced cervical cancer ( P >0.05 ) .β-tubulinⅢexpression was correlated with efficiency and operation rate with TP chemotherapy but not with PF chemotherapy .Conclusions In the neoadju-vant chemotherapy of locally advanced cervical cancers ,β-tubulinⅢexpression can be used as an important index to predict the effec-tive rate of combined chemotherapy containing paclitaxel and guide the patients to individual chemotherapy .