CAJ | 학술논문

目的：探讨贝前列素钠联合贝那普利对早期糖尿病肾病患者的尿微量白蛋白、血清超敏C反应蛋白（hs-CRP）和TNF-α的影响。方法：选择2010年3月至2013年3月我院肾内科120例早期糖尿病肾病患者，根据使用药物随机分为贝那普利组、贝前列素钠组和联合组，每组各40例，疗程均为20周，比较3组治疗前后24 h尿微量白蛋白（24 h-UMA）、血清hs-CRP和TNF-α的差异。结果：3组治疗后24 h-UMA、hs-CRP和TNF-α均显著降低（P ＜0．05）；联合组治疗后24 h-UMA、hs-CRP和TNF-α均低于其他2组（P＜0．05）。结论：贝前列素钠联合贝那普利对早期糖尿病肾病更具有协同保护作用，可能与下调体内微炎症有关。
목적：탐토패전렬소납연합패나보리대조기당뇨병신병환자적뇨미량백단백、혈청초민C반응단백（hs-CRP）화TNF-α적영향。방법：선택2010년3월지2013년3월아원신내과120례조기당뇨병신병환자，근거사용약물수궤분위패나보리조、패전렬소납조화연합조，매조각40례，료정균위20주，비교3조치료전후24 h뇨미량백단백（24 h-UMA）、혈청hs-CRP화TNF-α적차이。결과：3조치료후24 h-UMA、hs-CRP화TNF-α균현저강저（P ＜0．05）；연합조치료후24 h-UMA、hs-CRP화TNF-α균저우기타2조（P＜0．05）。결론：패전렬소납연합패나보리대조기당뇨병신병경구유협동보호작용，가능여하조체내미염증유관。
Objective To explore the effect of the combination of benazepril and beraprost sodium on urinary microalbumin (UMA), serum high sensitivity C-reactive protein (hs-CRP) and TNF-α in patients with diabetic nephropathy(DN) in early stage. Methods From Mar. 2010 to Mar. 2013, 120 patients with early-stage DN were randomly divided into Benazepril Group, Beraprost Sodium Group and Combination Group. Each group consisted of 40 patients with medical therapy in 20-week duration. The levels of 24 h-UMA, serum hs-CRP and TNF-α were detected and compared before and after therapy. Results After treatment, the levels of 24 h-UMA, serum hs-CRP and TNF-αall decreased significantly in three groups (P<0.05) and there were lower 24 h-UMA, serum hs-CRP and TNF-αin Combination Group than those in Benazepril Group and Berapros sodium Group (P <0.05). Conclusion There is coordinating protection of combination of benazepril and beraprost sodium on diabetic nephropathy in early stage, possibly being related with the inhibiting of micro-inflammation.