CAJ | 학술논문

采用湿法制粒压片法制备双孢蘑菇多糖分散片。以崩解时限，分散均匀性为考察指标，通过调节填充剂种类、崩解剂及润滑剂的用量，应用正交试验优化双孢蘑菇多糖分散片的处方。确定了双孢蘑菇多糖分散片的最佳处方为每片含双孢蘑菇多糖100 mg，交联羧甲基纤维素钠60 mg，微晶纤维素232 mg，滑石粉8 mg。按优化处方制备3批分散片，其崩解时限和分散均匀性均符合要求，且重现性良好。该处方工艺简单易行，成本较低，可以用于双孢蘑菇多糖分散片的制备。
채용습법제립압편법제비쌍포마고다당분산편。이붕해시한，분산균균성위고찰지표，통과조절전충제충류、붕해제급윤활제적용량，응용정교시험우화쌍포마고다당분산편적처방。학정료쌍포마고다당분산편적최가처방위매편함쌍포마고다당100 mg，교련최갑기섬유소납60 mg，미정섬유소232 mg，활석분8 mg。안우화처방제비3비분산편，기붕해시한화분산균균성균부합요구，차중현성량호。해처방공예간단역행，성본교저，가이용우쌍포마고다당분산편적제비。
The immediate release tablets of Agaricus bisporus polysaccharide were prepared through the wet granulation and compression methods. With the index of disintegrating time and dispersible uniformity , the formulation was optimized with orthogonal experimental design through adjusting the fillers and the contents of disintegrating agents and lubricants. The optimum formulation was obtained as 100 mg Agaricus bisporus polysaccharide, 60 mg croscarmellose sodium, 232 mg microcrystalline cellulose and 8 mg talcum powder (per tablet). According to the formulation, 3 batches of Agaricus bisporus polysaccharide immediate release tablets were prepared successfully with the qualified disintegrating time and dispersible uniformity. The optimized formulation is reasonable for preparation of Agaricus bisporus polysaccharide immediate release tablets.