CAJ | 학술논문

目的：比较γ-干扰素释放试验TB-IGRA和T-SPOT.TB检测结核分枝杆菌潜伏感染的效能和一致性。方法分别用TB-IGRA和T-SPOT.TB两种方法对18例志愿者、4例涂阳肺结核患者及1例非结核分枝杆菌感染者的外周血标本中特异性γ-干扰素的含量进行检测，进行平行比较分析。结果 TB-IGRA法和T-SPOT.TB法的敏感性、特异性、阳性预测值、阴性预测值均为100%,2种方法的Youden指数均为1，差异无统计学意义(P＞0.05)。结论 TB-IGRA和T-SPOT.TB两种方法在诊断结核分枝杆菌潜伏感染方面有较好的效能和一致性，有临床应用价值，阴性结果在结核病鉴别诊断中有较重要的临床意义。
목적：비교γ-간우소석방시험TB-IGRA화T-SPOT.TB검측결핵분지간균잠복감염적효능화일치성。방법분별용TB-IGRA화T-SPOT.TB량충방법대18례지원자、4례도양폐결핵환자급1례비결핵분지간균감염자적외주혈표본중특이성γ-간우소적함량진행검측，진행평행비교분석。결과 TB-IGRA법화T-SPOT.TB법적민감성、특이성、양성예측치、음성예측치균위100%,2충방법적Youden지수균위1，차이무통계학의의(P＞0.05)。결론 TB-IGRA화T-SPOT.TB량충방법재진단결핵분지간균잠복감염방면유교호적효능화일치성，유림상응용개치，음성결과재결핵병감별진단중유교중요적림상의의。
Objective To compare efficiency and consistency of type interferon gamma release assay on detecting mycobacterium tuberculosis latent infection by two different methods of TB-IGRA and T-SPOT.TB. Method Detect the specific IFN-γ of 18 volunteers, 4 patients with smear positive pulmonary tuberculosis, 1 case of non tuberculous mycobacterial infection for paral el comparative analysis by the two different methods. Results Sensitivity, specificity, positive predictive value, and negative predictive value of TB -IGRA and T-SPOT. TB were 100%, Youden index of the two methods was 1, indicating no statistical y significant (P > 0.05). Conclusion TB-IGRA and T-SPOT.TB have good consistency in the diagnosis of mycobacterium tuberculosis latent infection with a good clinical application value, and the negative result has a valuable significance in the differential diagnosis of tuberculosis.