CAJ | 학술논문

目的：观察CAPRI细胞治疗慢性乙型肝炎的疗效及其对T细胞亚群的影响。方法采用流式细胞术等检测6例慢性乙型肝炎患者接受CAPRI细胞治疗前和治疗后4周血常规、肝功能、乙肝病毒DNA、T细胞亚群(CD4+、CD8+)的变化。结果接受CAPRI细胞治疗的6例慢性乙型肝炎患者，ALT(p<0.05)和乙肝病毒DNA（p<0.01）均明显降低；外周血T淋巴细胞(p<0.05)、CD4+T细胞（p<0.05）、CD8+T细胞（p<0.01）数目均明显增加，CD4+/CD8+由1.28±0.08降至0.98±0.05(p<0.05)，差异有统计学意义。结论 CAPRI细胞治疗慢性乙型肝炎可降低乙肝病毒DNA水平，改善肝功能；CD8+T淋巴细胞在CAPRI细胞治疗慢性乙型肝炎中发挥主要作用。
목적：관찰CAPRI세포치료만성을형간염적료효급기대T세포아군적영향。방법채용류식세포술등검측6례만성을형간염환자접수CAPRI세포치료전화치료후4주혈상규、간공능、을간병독DNA、T세포아군(CD4+、CD8+)적변화。결과접수CAPRI세포치료적6례만성을형간염환자，ALT(p<0.05)화을간병독DNA（p<0.01）균명현강저；외주혈T림파세포(p<0.05)、CD4+T세포（p<0.05）、CD8+T세포（p<0.01）수목균명현증가，CD4+/CD8+유1.28±0.08강지0.98±0.05(p<0.05)，차이유통계학의의。결론 CAPRI세포치료만성을형간염가강저을간병독DNA수평，개선간공능；CD8+T림파세포재CAPRI세포치료만성을형간염중발휘주요작용。
Objective Assess the curative effect of CAPRI cells in the treatment of chronic hepatitis B patients, and explore its impact on T cellsubsets to further find the underlying mechanism of CAPRI cells. Methods With the informed consent of 6 patients, each patient was given one period of treatment with CAPRI cells. Routine examination of blood, liver function and the load of hepatitis B virus, as wel as T cellsubsets were performed before treatment and four weeks after treatment. Results ALT (p<0.05) and HBV DNA (p<0.05) were reduced, while the absolute number of peripheral lymphocytes (p<0.05), CD4+T cells and CD8+T cells(p<0.01)were increased. The rate of CD4+/CD8+ reduced to 0.98±0.05 from 1.28±0.08 (p<0.05). Conclusions CAPRI cells could reduce the load of hepatitis B virus and improve the liver function of chronic hepatitis B patients. CD8+T lymphocytes might play an important role in this process.