CAJ | 학술논문

近年来发展起来的肿瘤干细胞理论认为：肿瘤是一种干细胞疾病，由成体干细胞恶性转变而来的肿瘤干细胞是癌症发生发展、转移复发和对放化疗药物耐药的根源。Musashi1是一种进化比较保守的神经 RNA 结合蛋白，最早在果蝇的感觉器官中被发现，认为可能与果蝇发育过程中感觉器官的细胞分化有关，对维持神经干细胞或祖细胞的干细胞特性具有重要作用。越来越多的研究显示干细胞标志物 Musashi1在多种肿瘤中高表达，与肿瘤和肿瘤干细胞的关系密切，参与了肿瘤的发生、发展、浸润和转移，是肿瘤潜在的诊断标志物、预后指标和治疗靶点。
근년래발전기래적종류간세포이론인위：종류시일충간세포질병，유성체간세포악성전변이래적종류간세포시암증발생발전、전이복발화대방화료약물내약적근원。Musashi1시일충진화비교보수적신경 RNA 결합단백，최조재과승적감각기관중피발현，인위가능여과승발육과정중감각기관적세포분화유관，대유지신경간세포혹조세포적간세포특성구유중요작용。월래월다적연구현시간세포표지물 Musashi1재다충종류중고표체，여종류화종류간세포적관계밀절，삼여료종류적발생、발전、침윤화전이，시종류잠재적진단표지물、예후지표화치료파점。
In recent years,the cancer stem cell theory considers that the tumor is a kind of stem cell disease,and tumor stem cells which transformate from adult stem cells are the root cause of cancer development,recurrence and metastasis,and resistance to radiation and chemotherapy drugs.Musashi1 is a RNA-binding protein that was initially identified in Drosophila sense organ,is related with cell differentiation of sense organ during Drosophila development,and plays an important role in maintenance of stem cell characteristics of neural stem cells or progenitor cells.More and more studies have shown that stem cell marker Musashi1 highly expresses in a variety of tumors,is closely related to tumor and tumor stem cells,and involved in the occurrence,development,invasion and metastasis of tumor.Musashi1 can be used as a potential diagnostic marker,prognostic factor,and therapeutic target in tumors.