CAJ | 학술논문

呼吸机相关性肺炎(VAP)是 ICU 患者进行机械通气后病情加重甚至死亡的原因之一。传统预测感染的指标对 VAP 的诊断敏感性、特异性不高，其预测价值有限。血清降钙素原(PCT)检测在VAP 预测中较传统的炎性指标具有较高的灵敏性和特异性。国外研究发现，当人体发生细菌感染以及发生脓毒症时血清 PCT 浓度升高，具有一定的诊断价值。监测 PCT 的变化可能有助于 VAP 的早期诊断以及及时调整抗生素的使用。本文就 VAP 的诊断、治疗及预后几方面，综述 PCT 在 VAP 患者中的应用。
호흡궤상관성폐염(VAP)시 ICU 환자진행궤계통기후병정가중심지사망적원인지일。전통예측감염적지표대 VAP 적진단민감성、특이성불고，기예측개치유한。혈청강개소원(PCT)검측재VAP 예측중교전통적염성지표구유교고적령민성화특이성。국외연구발현，당인체발생세균감염이급발생농독증시혈청 PCT 농도승고，구유일정적진단개치。감측 PCT 적변화가능유조우 VAP 적조기진단이급급시조정항생소적사용。본문취 VAP 적진단、치료급예후궤방면，종술 PCT 재 VAP 환자중적응용。
Ventilator associated pneumonia (VAP)is one of the reasons of desease aggravation and even death for ventilated patients in ICU.The sensitivity and specificity of traditional indexes of forecasting infection are not high in the diagnosis of VAP,and its predictive value is limited.The detection of serum procalcitonin (PCT)has more higher sensitivity and specificity in the predictive role of VAP compared with traditional inflammatory indexes.Foreign studies have found that the level of serum PCT increases when bacterial infection or sepsis occurs in the body,which has certain diagnostic value. Monitoring the change of the PCT level may be helpful in the early diagnosis of VAP and adjusting the use of antibiotics in time.From the diagnosis,treatment,and prognosis of VAP,this paper reviews the PCT application in the patients with VAP.