国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
8期
573-575
,共3页
百草枯%乌司他丁%复方丹参注射液%肺损伤
百草枯%烏司他丁%複方丹參註射液%肺損傷
백초고%오사타정%복방단삼주사액%폐손상
Paraquat%Ulinastatin%Danshen injection%Lung injury
目的:探究常规应用乌司他丁联合复方丹参注射液对百草枯中毒患者肺损伤的疗效。方法选取2010年7月至2013年7月来我院就诊的100例百草枯中毒患者,依据分层随机分组法将患者分为治疗组和对照组,每组50例。对照组给予积极的常规疗法及丹参注射液进行治疗,治疗组在常规治疗的基础上加用乌司他丁联合复方丹参注射液治疗。分别于治疗前及治疗2周后检测 PaO 2、PaCO 2及氧合指数,观察紫绀例数及 ARDS 发生例数,并于治疗前及治疗后1周、2周及4周检测患者的血清血红素氧合酶-1。结果治疗前两组检测指标差异无统计学意义;治疗2周后治疗组的 PaO 2、PaCO 2、氧合指数及血红素氧合酶-1明显高于对照组(t 值分别为3.520、2.597、2.425、2.197,P 值均<0.05),治疗组患者的紫绀及 ARDS 发生率均低于对照组(χ2值分别为5.316、4.971,P 值均<0.05)。结论百草枯中毒患者常规治疗基础上应用乌司他丁联合复方丹参注射液治疗可明显改善患者肺损伤指标,促进患者的损伤修复,建议临床积极推广。
目的:探究常規應用烏司他丁聯閤複方丹參註射液對百草枯中毒患者肺損傷的療效。方法選取2010年7月至2013年7月來我院就診的100例百草枯中毒患者,依據分層隨機分組法將患者分為治療組和對照組,每組50例。對照組給予積極的常規療法及丹參註射液進行治療,治療組在常規治療的基礎上加用烏司他丁聯閤複方丹參註射液治療。分彆于治療前及治療2週後檢測 PaO 2、PaCO 2及氧閤指數,觀察紫紺例數及 ARDS 髮生例數,併于治療前及治療後1週、2週及4週檢測患者的血清血紅素氧閤酶-1。結果治療前兩組檢測指標差異無統計學意義;治療2週後治療組的 PaO 2、PaCO 2、氧閤指數及血紅素氧閤酶-1明顯高于對照組(t 值分彆為3.520、2.597、2.425、2.197,P 值均<0.05),治療組患者的紫紺及 ARDS 髮生率均低于對照組(χ2值分彆為5.316、4.971,P 值均<0.05)。結論百草枯中毒患者常規治療基礎上應用烏司他丁聯閤複方丹參註射液治療可明顯改善患者肺損傷指標,促進患者的損傷脩複,建議臨床積極推廣。
목적:탐구상규응용오사타정연합복방단삼주사액대백초고중독환자폐손상적료효。방법선취2010년7월지2013년7월래아원취진적100례백초고중독환자,의거분층수궤분조법장환자분위치료조화대조조,매조50례。대조조급여적겁적상규요법급단삼주사액진행치료,치료조재상규치료적기출상가용오사타정연합복방단삼주사액치료。분별우치료전급치료2주후검측 PaO 2、PaCO 2급양합지수,관찰자감례수급 ARDS 발생례수,병우치료전급치료후1주、2주급4주검측환자적혈청혈홍소양합매-1。결과치료전량조검측지표차이무통계학의의;치료2주후치료조적 PaO 2、PaCO 2、양합지수급혈홍소양합매-1명현고우대조조(t 치분별위3.520、2.597、2.425、2.197,P 치균<0.05),치료조환자적자감급 ARDS 발생솔균저우대조조(χ2치분별위5.316、4.971,P 치균<0.05)。결론백초고중독환자상규치료기출상응용오사타정연합복방단삼주사액치료가명현개선환자폐손상지표,촉진환자적손상수복,건의림상적겁추엄。
Objective To explore the effects of conventional application of ulinastatin joint danshen injection on acute lung injury patients with paraquat poisoning.Methods 100 cases of paraquat poisoning patients treated in our hospital from July 2010 to July 2013 were selected.The patients were divided into treatment group (n =50)and control group (n =50)according to the stratified randomization method. The control group was given routine treatment and danshen injection,the treatment group was given ulinastatin on the basis of the treatment program of the control group.The respiratory function indexes such as PaO 2 ,PaCO 2 ,oxygenation index,the number of acute respiratory distress syndrome and pulmonary edema before and two weeks after treatment were compared between two groups.The serum heme oxygenase-1 before and one week,two weeks,four weeks after treatment was compared between two groups,too.Results There was no significant difference in the related indicators before treatment between the two groups.The PaO 2 ,PaCO 2 ,oxygenation index and heme oxygenase-1 in treatment group were higher than those in control group two weeks after treatment (t = 3.520,2.597,2.425,2.1 97,all P <0.05).The incidence rates of cyanosis and acute respiratory distress syndrome in treatment group were lower than those in control group two weeks after treatment (χ2 = 5.31 6,4.971,all P < 0.05 ). Conclusions Conventional application of ulinastatin joint danshen injection on acute lung injury patients with paraquat poisoning can improve clinical symptoms and promote lung damage repair significantly.It is strongly recommended to treat the patients with paraquat poisoning.