CAJ | 학술논문

目的：探讨胚胎移植管血染对IVF/ICSI助孕结局的影响。方法回顾性分析单中心行IVF/ICSI，并新鲜周期移植的患者资料。按照移植胚胎时移植管血染与否及血染程度分组，比较各组临床资料、实验室指标及随访结局。结果纳入2601个IVF/ICSI周期，血染组共847个周期，无血染组1754个周期。两组患者年龄、不孕年限、基础FSH等基本情况具有可比性，HCG日内膜厚度、获卵数、Gn总量、2PN受精率、移植胚胎数均差异无统计学意义（P＞0.05）。血染组种植率30.7％低于无血染组的34.8％（P＜0.01）；血染组临床妊娠率47.6％低于无血染组的54.1％（P＜0.05）。将血染组按血染程度分为少许血染、中量血染和明显血染3组，进行亚组分析显示种植率及临床妊娠率在3组间无明显差异（ P＞0.05）。单因素logistic回归分析显示移植管血染是影响临床妊娠的危险因素。结论移植管血染可能降低胚胎种植率、临床妊娠率。血染程度与胚胎种植率、临床妊娠率的关系还有待于进一步研究。
목적：탐토배태이식관혈염대IVF/ICSI조잉결국적영향。방법회고성분석단중심행IVF/ICSI，병신선주기이식적환자자료。안조이식배태시이식관혈염여부급혈염정도분조，비교각조림상자료、실험실지표급수방결국。결과납입2601개IVF/ICSI주기，혈염조공847개주기，무혈염조1754개주기。량조환자년령、불잉년한、기출FSH등기본정황구유가비성，HCG일내막후도、획란수、Gn총량、2PN수정솔、이식배태수균차이무통계학의의（P＞0.05）。혈염조충식솔30.7％저우무혈염조적34.8％（P＜0.01）；혈염조림상임신솔47.6％저우무혈염조적54.1％（P＜0.05）。장혈염조안혈염정도분위소허혈염、중량혈염화명현혈염3조，진행아조분석현시충식솔급림상임신솔재3조간무명현차이（ P＞0.05）。단인소logistic회귀분석현시이식관혈염시영향림상임신적위험인소。결론이식관혈염가능강저배태충식솔、림상임신솔。혈염정도여배태충식솔、림상임신솔적관계환유대우진일보연구。
Objective To evaluate the correlation between blood staining on the embryo transfer catheter and the outcome in fresh IVF/ICSI cycles .Methods Retrospective analysis was performed on the data about patients who under-went fresh long protocol IVF/ICSI cycle in a single IVF center .The cycles were grouped into three according to a semi-quantitative system for recording the amount of blood on the transfer catheter .The demographic data , implantation rate , and clinical pregnancy rate were noted and compared .Results A total of 2 601 cycles were examined , among which 1 754 cycles were without blood staining on the catheter during ET , while the other 847 cycles were associated with blood staining.The implantation rate (IR) and clinical pregnancy rate (CPR) in the group without blood staining were signifi-cantly higher than the group with blood staining ( 34.8% vs 30.7%, P=0.002; and 54.1% vs 47.6%, P value =0.013).However, there was no significant difference was found in IR or CPR among different groups of bloody staining degree.Conclusion Blood staining on the embryo transfer catheter may reduce the embryo implantation and clinical pregnancy rate.However, the degree of bloody staining may not worsen the clinical outcome .