CAJ | 학술논문

目的：探讨补肾化瘀中药干预对光老化大鼠模型表皮及真皮结构的影响。方法利用8-甲氧补骨脂素/长波紫外线UVA（320～400 nm）照射SD大鼠，建立光老化大鼠模型，并对该动物模型给予补肾化瘀中药干预，连续15 d。40只SD大鼠分为空白对照组（实验过程中不经紫外线照射和任何干预）10只、补肾化瘀中药干预组（紫外线照射造模后，给予补肾化瘀中药干预）15只、模型对照组（紫外线照射造模后，给予生理盐水灌胃）15只。采用皮肤组织病理学对3组大鼠的表皮及真皮结构改变进行观察和分析。结果成功建立光老化大鼠模型，补肾化瘀中药干预组大鼠损伤区皮肤外观及弹性趋向正常，组织形态学上光老化损伤表现基本消失，真皮层出现新生胶原纤维，排列紧密，弹力纤维分布均匀。结论补肾化瘀中药具有抗光老化作用，能够促进光老化大鼠皮肤损害的修复，为补肾化瘀中药抗光老化研究提供了客观的组织形态学依据。
목적：탐토보신화어중약간예대광노화대서모형표피급진피결구적영향。방법이용8-갑양보골지소/장파자외선UVA（320～400 nm）조사SD대서，건립광노화대서모형，병대해동물모형급여보신화어중약간예，련속15 d。40지SD대서분위공백대조조（실험과정중불경자외선조사화임하간예）10지、보신화어중약간예조（자외선조사조모후，급여보신화어중약간예）15지、모형대조조（자외선조사조모후，급여생리염수관위）15지。채용피부조직병이학대3조대서적표피급진피결구개변진행관찰화분석。결과성공건립광노화대서모형，보신화어중약간예조대서손상구피부외관급탄성추향정상，조직형태학상광노화손상표현기본소실，진피층출현신생효원섬유，배렬긴밀，탄력섬유분포균균。결론보신화어중약구유항광노화작용，능구촉진광노화대서피부손해적수복，위보신화어중약항광노화연구제공료객관적조직형태학의거。
Objective To study on the influence of replenishing kidney dissolving blood stasistherapy on epider -mis and dermis structure of photoaging skin rat models .Methods Using 8-methoxypsoralan/UVA ray (320~400 nm) irradiation was applied on SD rats for establishment of skin photoaging rat model .The intervention of replenishing kidney dissolving blood stasis therapy was given for 15 days in a row.Histopathological observation was performed for analysis of the changes of epidermis and the dermis structure of rats in control group , photoaging group and intervention group . Results The photoaging rat model was established successfully .The tended normal appearance and elasticity of damaged areas, almost disappeared glazing aging damage performance , new densely arranged dermis collagen fiber , and evenly dis-tributed elastic fiber were observed in therapy group .Conclusion Replenishing kidney dissolving blood stasis therapy provides anti-photoaging effect in photoaging rats , and promotes the repairmen of impaired skins .