CAJ | 학술논문

目的：观察泮托拉唑联合莫沙必利治疗反流性食管炎的临床疗效。方法：选取2009年10月至2012年12月就诊病例86例,将其随机分为两组，分别是治疗组、对照组，每组各43例患者。治疗组：泮托拉唑胶囊40 mg口服,1次/日；莫沙必利片5mg口服,3次/日。对照组：雷尼替丁胶囊10mg口服3次/日；吗丁啉片10mg 饭前半小时口服，3次/日。治疗组、对照组两组患者在治疗之后4周，对其服药期间所出现的不良反应进行详细的记录，同时还应该复查内镜和观察临床症状。结果：结果显示，治疗后两组症状和内镜总有效率均有显著性差（P<0.05），即泮托拉唑联合莫沙必利治疗反流性食管炎疗效优于雷尼替丁联合吗丁啉。43例治疗组患者在服药后出现1例腹痛,2例出现大便次数增多的情况；而43例对照组患者在服药后出现1例头晕，1例口干，1例出现大便次数增多的情况.治疗组和对照组患者之间所出现的不良反应不存在较为明显的差异，也不会对继续治疗造成较大的影响。结论：泮托拉唑联合莫沙必利治疗反流性食管炎疗效优于雷尼替丁加吗丁啉，副作用小，是安全有效的药物。
목적：관찰반탁랍서연합막사필리치료반류성식관염적림상료효。방법：선취2009년10월지2012년12월취진병례86례,장기수궤분위량조，분별시치료조、대조조，매조각43례환자。치료조：반탁랍서효낭40 mg구복,1차/일；막사필리편5mg구복,3차/일。대조조：뢰니체정효낭10mg구복3차/일；마정람편10mg 반전반소시구복，3차/일。치료조、대조조량조환자재치료지후4주，대기복약기간소출현적불량반응진행상세적기록，동시환응해복사내경화관찰림상증상。결과：결과현시，치료후량조증상화내경총유효솔균유현저성차（P<0.05），즉반탁랍서연합막사필리치료반류성식관염료효우우뢰니체정연합마정람。43례치료조환자재복약후출현1례복통,2례출현대편차수증다적정황；이43례대조조환자재복약후출현1례두훈，1례구간，1례출현대편차수증다적정황.치료조화대조조환자지간소출현적불량반응불존재교위명현적차이，야불회대계속치료조성교대적영향。결론：반탁랍서연합막사필리치료반류성식관염료효우우뢰니체정가마정람，부작용소，시안전유효적약물。
Objective:To observe the clinical effects of pantoprazole combined with mosapride on treatment of reflux esophagitis. Method:86 cases of patients visited from October in 2009 to December in 2012 were selected to be divided into two groups which were treatment group and control group with 43 cases respectively. For treatment group:oral administration of 40mg of pantoprazole capsule, once a day, and oral administration of 5mg of mosapride tablet, three times a day. For control group:oral administration of 10mg of ranitidine capsules, three times a day, and oral administration of 10mg of motilium tablet half an hour before meals, three times a day. After 4 weeks of treatment, the adverse reaction of patients of both groups during the medication was recorded in details. At the same time, the patients were re-examined under endoscope to observe their clinical symptoms. Result:The result displays that the total effective rate of symptoms and endoscope of both groups had significant significance (P<0.05), i.e., the curative effect of pantoprazole combined with mosapride on treatment of reflux esophagitis was bet er than that of ranitidine combined with motilium. Among the 43 cases of patients in treatment group, 1 case of abdominal pain and 2 cases of increased stool frequency emerged after taking the medicine. Among the 43 cases of patients in control group, 1 case of dizziness, 1 case of dry mouth and 1 case of increased stool frequency emerged after taking the medicine. There were not significant differences of the adverse reaction between treatment group and control group and there would be no great influence on the further treatment. Conclusion:With few side effects, the curative effect of pantoprazole combined with mosapride on treatment of reflux esophagitis is bet er than that of ranitidine combined with motilium and they are secure and effective drugs.