中国保健营养(中旬刊)
中國保健營養(中旬刊)
중국보건영양(중순간)
China Hwalth Care & nutrition
2013年
7期
201-202
,共2页
郭会霞%LIU Zeng-long%ZHOU Hui-shuang%CHEN Guo-hua
郭會霞%LIU Zeng-long%ZHOU Hui-shuang%CHEN Guo-hua
곽회하%LIU Zeng-long%ZHOU Hui-shuang%CHEN Guo-hua
抗精神病药物%氯氮平%托吡酯%脑电图
抗精神病藥物%氯氮平%託吡酯%腦電圖
항정신병약물%록담평%탁필지%뇌전도
antipsychotic drugs%clozapine%topiramate%EEG
目的:探讨托吡酯对氯氮平所致脑电图异常干预的研究。方法:采用前瞻性平行对照方法共纳入72例稳定服用治疗剂量或维持剂量的氯氮平患者,随机分为两组,一组合并托吡酯治疗(研究组),另一组单用氯氮平治疗(对照组)。研究组:对照组=1:1,观察治疗6月,定期测体重、腰围、血糖、血脂、心电图、脑电图、肝功能(AST ALT GGT)、氯氮平血药浓度、血常规、UKU 不良反应量表。对研究组与对照组的临床资料进行比较。结果:两组的氯氮平治疗剂量间差异无显著性(t=0.628,P=0.53);基线时研究组和对照组脑电图异常率分别是55.56%和64.52%.治疗2、4、6月后两组相比差异有统计学意义,直到第6月末(X2=4.1852~11.7109,P<0.05或0.01);研究组自身对比,第6月末与基线比较差异具有统计学意义(X2=4.9091,P<0.05)。结论:托吡酯可改善由于应用氯氮平所致的脑电图异常,从而减少氯氮平所致癫痫发作。
目的:探討託吡酯對氯氮平所緻腦電圖異常榦預的研究。方法:採用前瞻性平行對照方法共納入72例穩定服用治療劑量或維持劑量的氯氮平患者,隨機分為兩組,一組閤併託吡酯治療(研究組),另一組單用氯氮平治療(對照組)。研究組:對照組=1:1,觀察治療6月,定期測體重、腰圍、血糖、血脂、心電圖、腦電圖、肝功能(AST ALT GGT)、氯氮平血藥濃度、血常規、UKU 不良反應量錶。對研究組與對照組的臨床資料進行比較。結果:兩組的氯氮平治療劑量間差異無顯著性(t=0.628,P=0.53);基線時研究組和對照組腦電圖異常率分彆是55.56%和64.52%.治療2、4、6月後兩組相比差異有統計學意義,直到第6月末(X2=4.1852~11.7109,P<0.05或0.01);研究組自身對比,第6月末與基線比較差異具有統計學意義(X2=4.9091,P<0.05)。結論:託吡酯可改善由于應用氯氮平所緻的腦電圖異常,從而減少氯氮平所緻癲癇髮作。
목적:탐토탁필지대록담평소치뇌전도이상간예적연구。방법:채용전첨성평행대조방법공납입72례은정복용치료제량혹유지제량적록담평환자,수궤분위량조,일조합병탁필지치료(연구조),령일조단용록담평치료(대조조)。연구조:대조조=1:1,관찰치료6월,정기측체중、요위、혈당、혈지、심전도、뇌전도、간공능(AST ALT GGT)、록담평혈약농도、혈상규、UKU 불량반응량표。대연구조여대조조적림상자료진행비교。결과:량조적록담평치료제량간차이무현저성(t=0.628,P=0.53);기선시연구조화대조조뇌전도이상솔분별시55.56%화64.52%.치료2、4、6월후량조상비차이유통계학의의,직도제6월말(X2=4.1852~11.7109,P<0.05혹0.01);연구조자신대비,제6월말여기선비교차이구유통계학의의(X2=4.9091,P<0.05)。결론:탁필지가개선유우응용록담평소치적뇌전도이상,종이감소록담평소치전간발작。
Objective:To evaluate topiramate on clozapine induced abnormal EEG intervention studies. Methods:A prospective parallel controlled method of taking were included 72 cases of stable therapeutic dose or maintenance dose of clozapine were randomly divided into two groups, and a combination of topiramate treatment (study group), another group of clozapine treatment alone (control group). Study groups: control group = 1:1 ,the two groups were observed for 6 months, regularly measured weight, waist circumference, blood glucose, blood lipids, ECG, EEG, liver function (AST ALT GGT) ,plasma concentrations of clozapine, Blood routine, UKU adverse response scale. The study group and control group to compare the clinical data. Results:The dose of clozapine in treatment between the two groups was no significant difference (t = 0.628, P = 0.53); baseline study group and control group of EEG abnormalities rates were 55.56% and 64.52%. 2,4,6 months after treatment compared with differences between the two groups was statistically significant to the end of the sixth months, (X2=4.1852~11.7109,P<0.05或0.01);Comparative Study Group's own,No. 6 at the end with the statistically significant difference between the baseline(X2=4.9091,P<0.05).Conclusion:Topiramate can be improved due to application of clozapine-induced EEG abnormalities, thereby reducing clozapine induced seizures.