CAJ | 학술논문

目的：观察玻璃体腔注射曲安奈德后角膜内皮细胞的变化。方法收集我院行玻璃体腔注射曲安奈德的病人11例11眼，依据所患疾病不同进行分组，即视网膜静脉阻塞组6例和糖尿病性视网膜病变组5例，用角膜内皮细胞仪记录术前及术后第1、3天角膜内皮细胞密度、六边形细胞所占比例的变化。结果玻璃体腔注射曲安奈德术后1d ，角膜内皮细胞密度较术前增加者8例，其中RVO组6例，DR组2例；术后3d ，角膜内皮细胞密度较术前增加者6例，其中RVO组5例，DR组1例。RVO组，术后1d、3d角膜内皮细胞密度分别为（2849．2±224．6）／mm2、（2805．5±287．9）／mm2，均高于术前（2692．8±210．2）／mm2，差异均有统计学意义（均为 P＜0．05）。DR组，术后1d、3d角膜内皮细胞密度分别为（2451．4±439．7）／mm2、（2403．4±316．2）／mm2均低于术前（2501．6±496．0）／mm2，差异均有统计学意义（均为 P＜0．05）。RVO组和DR组术后不同时间点角膜内皮六边形细胞比例明显降低，均低于术前，差异均有统计学意义（均为 P＜0．05），但术后各时间点间比较，差异均无统计学意义（均为 P＞0．05）。结论视网膜静脉阻塞患者及糖尿病视网膜病变患者术后角膜内皮细胞形态和功能均出现一定程度的变化，糖尿病患者角膜内皮细胞损伤较大。
목적：관찰파리체강주사곡안내덕후각막내피세포적변화。방법수집아원행파리체강주사곡안내덕적병인11례11안，의거소환질병불동진행분조，즉시망막정맥조새조6례화당뇨병성시망막병변조5례，용각막내피세포의기록술전급술후제1、3천각막내피세포밀도、륙변형세포소점비례적변화。결과파리체강주사곡안내덕술후1d ，각막내피세포밀도교술전증가자8례，기중RVO조6례，DR조2례；술후3d ，각막내피세포밀도교술전증가자6례，기중RVO조5례，DR조1례。RVO조，술후1d、3d각막내피세포밀도분별위（2849．2±224．6）／mm2、（2805．5±287．9）／mm2，균고우술전（2692．8±210．2）／mm2，차이균유통계학의의（균위 P＜0．05）。DR조，술후1d、3d각막내피세포밀도분별위（2451．4±439．7）／mm2、（2403．4±316．2）／mm2균저우술전（2501．6±496．0）／mm2，차이균유통계학의의（균위 P＜0．05）。RVO조화DR조술후불동시간점각막내피륙변형세포비례명현강저，균저우술전，차이균유통계학의의（균위 P＜0．05），단술후각시간점간비교，차이균무통계학의의（균위 P＞0．05）。결론시망막정맥조새환자급당뇨병시망막병변환자술후각막내피세포형태화공능균출현일정정도적변화，당뇨병환자각막내피세포손상교대。
Objective To observation of changes of corneal endothelial cellsby intravitreal Triamcinolone Acetonide .Methods A total of 11 patients(11 eyes)were selected in our hospital ,they all received intravitreal Triamcinolone Acetonide ,and then divided into two groups :retinal vein occlusion(RVO) group(6 cases ,6 eyes) and diabetic retinopathy (DR) group(5 cases ,5 eyes) .All cases received intravitreal Triamcinolone Acetonide .At preoperative and postoperative 1 day ,3 day ,the corneal endothelial in the central region were detected by corneal endothelial cell instrument without touching .The changes of corneal endothelial cell density ,hexagonal cells were observed .Results At postoperative 1 day ,corneal endothelial cell density of 8 patients were higher than that before operation ,RVO group 6 cases and DR group 2 cases . At postoperative 3 day ,corneal endothelial cell density of 6 patients were higher than that before operation , RVO group 5 cases and DR group 1 cases .In RVO group ,corneal endothelial cell density at postoperative 1 day ,3 day were(2849 .2 ± 224 .6)/mm2 and (2805 .5 ± 287 .9)/mm2 ,respectively .They were all higher than that before operation (2692 .8 ± 210 .2)/mm2 ,and there was significant difference (all P< 0 .05) .In DR group ,they were(2451 .4 ± 439 .7)/mm2 、(2403 .4 ± 316 .2)/mm2 ,respectively .They were all lower than that before operation(2501 .6 ± 496 .0)/mm2 ,and there was significant difference(all P<0 .05) .Both of RVO group and CRVO group ,hexagonal cells at different times points decreased obviously ,they were all lower than that before operation ,and there was significant difference(all P<0 .05) .But compared with different times points ,there was no significant difference(all P>0 .05) .Conclusion The appearance and function of corneal endothelial cells in RVO patients and DR patients change on some degree ,but the damage of corneal endothelial cells in DR patients is more serious .