中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2014年
2期
141-145
,共5页
高血压病%G蛋白β3亚单位%基因多态性%中国人群%Meta分析
高血壓病%G蛋白β3亞單位%基因多態性%中國人群%Meta分析
고혈압병%G단백β3아단위%기인다태성%중국인군%Meta분석
Hypertension%G-protein beta3 subunit%Polymorphism%Chinese population%Meta-analysis
目的：系统评价G蛋白β3亚单位（GNB3）基因825C/T多态性与中国人群原发性高血压（EH）发病风险的关系。方法由两名评价者独立检索PubMed、EMbase、CNKI、CBM和WanFang数据库，收集探讨GNB3基因825C/T多态性与中国人EH相关性的病例-对照研究，检索时限均为建库至2013年9月30日。文献筛选及资料提取后，对纳入文献按NOS进行质量评价，然后采用Stata12.0软件行Meta分析。结果最终纳入30个病例-对照研究，包括EH患者5054例，对照人群5565例。Meta分析结果显示，与对照组相比，GNB3基因825C/T多态性与中国人EH发病风险间无统计学差异[TT vs. CC：（OR=1.13，95%CI：0.89～1.43，P=0.33）；TT vs. CT+CC：（OR=1.04，95%CI：0.86～1.26，P=0.70）；CT vs. CC：（OR=1.08，95%CI：0.98～1.19，P=0.11）；TT+CT vs. CC：（OR=1.11，95%CI：0.96～1.29， P=0.15）；T vs. C：（OR=1.06，95%CI：0.95～1.20，P=0.30）]。结论当前证据表明中国人群GNB3基因825C/T多态性与EH发病无关。
目的：繫統評價G蛋白β3亞單位（GNB3）基因825C/T多態性與中國人群原髮性高血壓（EH）髮病風險的關繫。方法由兩名評價者獨立檢索PubMed、EMbase、CNKI、CBM和WanFang數據庫，收集探討GNB3基因825C/T多態性與中國人EH相關性的病例-對照研究，檢索時限均為建庫至2013年9月30日。文獻篩選及資料提取後，對納入文獻按NOS進行質量評價，然後採用Stata12.0軟件行Meta分析。結果最終納入30箇病例-對照研究，包括EH患者5054例，對照人群5565例。Meta分析結果顯示，與對照組相比，GNB3基因825C/T多態性與中國人EH髮病風險間無統計學差異[TT vs. CC：（OR=1.13，95%CI：0.89～1.43，P=0.33）；TT vs. CT+CC：（OR=1.04，95%CI：0.86～1.26，P=0.70）；CT vs. CC：（OR=1.08，95%CI：0.98～1.19，P=0.11）；TT+CT vs. CC：（OR=1.11，95%CI：0.96～1.29， P=0.15）；T vs. C：（OR=1.06，95%CI：0.95～1.20，P=0.30）]。結論噹前證據錶明中國人群GNB3基因825C/T多態性與EH髮病無關。
목적：계통평개G단백β3아단위（GNB3）기인825C/T다태성여중국인군원발성고혈압（EH）발병풍험적관계。방법유량명평개자독립검색PubMed、EMbase、CNKI、CBM화WanFang수거고，수집탐토GNB3기인825C/T다태성여중국인EH상관성적병례-대조연구，검색시한균위건고지2013년9월30일。문헌사선급자료제취후，대납입문헌안NOS진행질량평개，연후채용Stata12.0연건행Meta분석。결과최종납입30개병례-대조연구，포괄EH환자5054례，대조인군5565례。Meta분석결과현시，여대조조상비，GNB3기인825C/T다태성여중국인EH발병풍험간무통계학차이[TT vs. CC：（OR=1.13，95%CI：0.89～1.43，P=0.33）；TT vs. CT+CC：（OR=1.04，95%CI：0.86～1.26，P=0.70）；CT vs. CC：（OR=1.08，95%CI：0.98～1.19，P=0.11）；TT+CT vs. CC：（OR=1.11，95%CI：0.96～1.29， P=0.15）；T vs. C：（OR=1.06，95%CI：0.95～1.20，P=0.30）]。결론당전증거표명중국인군GNB3기인825C/T다태성여EH발병무관。
Objective To review systematically the relationship between C825T gene polymorphism of GNB3 and risk of essential hypertension (EH) in Chinese population. Methods The databases of PubMed, Embase, CNKI, CBM and WangFang Database were retrieved independently by 2 reviewers for collecting the case-control studies on correlation between C825T gene polymorphism of GNB3 and EH in Chinese population from database establish time to Sept. 2013. After literatre screening and data extracting, the included studies were given quality reviewing according to NOS and a Meta-analysis by using Stata12.0 software. Results There were 30 case-control studies included involving 5054 EH patients and 5565 control persons. The results of Meta-analysis showed that between C825T gene polymorphism of GNB3 and risk of EH had no statistical difference in Chinese population [TT vs. CC:(OR=1.13, 95%CI:0.89-1.43, P=0.33);TT vs. CT+CC:(OR=1.04, 95%CI:0.86-1.26, P=0.70);CT vs. CC:(OR=1.08, 95%CI:0.98-1.19, P=0.11);TT+CT vs. CC:(OR=1.11, 95%CI:0.96-1.29, P=0.15);T vs. C:(OR=1.06, 95%CI:0.95-1.20, P=0.30)]. Conclusion The current evidence indicates that C825T gene polymorphism of GNB3 is not correlated to risk of EH.
