CAJ | 학술논문

对痛风立消化合物的制剂基质进行筛选，采用单因素筛选法和正交设计试验，以体外释放度为主要考察指标，筛选该化合物制剂基质的最优处方。最优处方比例为：药料质量之比1∶10，壳聚糖5％，乙醇百分比25％。采用筛选后的最优处方制得的制剂释药特性符合设计要求。
대통풍립소화합물적제제기질진행사선，채용단인소사선법화정교설계시험，이체외석방도위주요고찰지표，사선해화합물제제기질적최우처방。최우처방비례위：약료질량지비1∶10，각취당5％，을순백분비25％。채용사선후적최우처방제득적제제석약특성부합설계요구。
Both the single factor screening and orthogonal test are applied to screen the preparation matrix of Gout Li Xiao compounds .With vitro release rate as main index ,the optimal formulation of the compound preparation matrix are chosen ,and the results show that the optimal prescription ratio is as follow s :the mass ratio of 1∶10 ,chitosan 5% ,ethanol percentage 25% .Based on the optimal prescription ,the preparation release characteristics meet the requirements .